AI Article Synopsis
- Tumours consist of various noncancerous cells that have both supportive and suppressive functions in their surrounding environment.
- The growing interest in these interactions has led to an increase in 3D in vitro models that replicate the complexity of the tumor microenvironment.
- This review explores methods for creating and analyzing these sophisticated models, focusing on how to effectively combine different cell types and extract meaningful insights from the complex cellular interactions.
Article Abstract
Tumours are surrounded by a host of noncancerous cells that fulfil both supportive and suppressive roles within the tumour microenvironment (TME). The drive to understand the biology behind each of these components has led to a rapid expansion in the number and use of 3D in vitro models, as researchers find ways to incorporate multiple cell types into physiomimetic configurations. The use and increasing complexity of these models does however demand many considerations. In this review we discuss approaches adopted to recapitulate complex tumour biology in tractable 3D models. We consider how these cell types can be sourced and combined and examine methods for the deconvolution of complex multicellular models into manageable and informative outputs.
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| http://dx.doi.org/10.1016/j.trecan.2021.06.009 | DOI Listing |
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