Centro de Desenvolvimento Tecnológico, Núcleo de Biotecnologia, Universidade Federal de Pelotas, CP 354, CEP 96160-000, Pelotas, RS, Brazil.
Published: August 2021
AI Article Synopsis
Article Abstract
Clostridium septicum (CS) is a pathogen that can cause the death of animals in livestock worldwide through its main virulence factor, alpha-toxin (ATX). The aspects involved in diseases caused by ATX, such as economic impact, prevalence, and rapid clinical course, require that animals should be systematically immunized. This review provides an overview of CS in livestock farming and discusses current immunization methods. Currently, commercial vaccines available against CS involve the cultivation and inactivation of microorganisms and toxins using a time-consuming, expensive, and high biological risk-carrying production platform, and some have been reported to be ineffective. An alternative to this process is the recombinant DNA technology, although recombinant ATX obtained thus far is no longer efficient in stimulating protective antibody titers despite improvements in the production methods. On the other hand, immunized animals have highly favorable levels of survival when subjected to challenge tests, suggesting that high titers of circulating serum antibodies may not be representative of protection after immunization and that the non-immune cellular defenses associated with the particularities of the mechanism of action of ATX may be involved in the immune response of the host. To contribute to the future of global livestock farming through the development of more efficient recombinant vaccines, we suggest novel perspectives and strategies, such as the location of immunodominant epitopes, expression of relevant functional domains, and construction of chimeras, in the rational design of recombinant ATX.
Introduction: Gas gangrene is a rare, often lethal infection of soft tissue that is commonly associated with the Clostridial species due to penetrating injuries. Case reports of spontaneous atraumatic gas gangrene due to the Clostridium septicum species are exceedingly rare. Atraumatic C.
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan. Electronic address:
Purpose: Costridium septicum, the causative agent of clostridial myonecrosis or gas gangrene, has been linked with colorectal malignancies, particularly tumors of the ascending colon. Due to the pathogen's resistance and the limited understanding of its genomic structure, effective therapeutic strategies are needed. This study focuses on developing a vaccine to address this issue.
Clostridial infections in cattle are a significant concern for Brazilian livestock. These diseases are caused by various species of , which are known for their ability to produce potent toxins. Botulism in cattle is a serious and often fatal condition caused by the ingestion of neurotoxins produced by .
Gas gangrene is a rare but severe infection often caused by the pathogen Clostridium septicum, which can develop either from trauma or spontaneously, particularly in patients with conditions like occult colon carcinoma.
Individuals with diabetes mellitus are at a higher risk for developing this infection, which has a high mortality rate of around 50%, even with aggressive treatment.
Initial symptoms are vague, complicating early diagnosis, and treatment typically involves high-dose antibiotics, surgical removal of infected tissue, and sometimes hyperbaric oxygen therapy.
Gas gangrene is a serious infection caused by Clostridium bacteria, often resulting in rapid tissue death and requiring quick, multidisciplinary medical intervention.
The case describes a 62-year-old woman with neutropenic fever from chemotherapy for breast cancer, who initially showed signs of cellulitis but deteriorated into septic shock despite antibiotic treatment.
After extensive surgical intervention and adjustment of her antibiotics, the patient stabilized and was eventually discharged for rehabilitation, underscoring the diagnostic and therapeutic challenges associated with infections in immunocompromised individuals.
