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Background: To investigate whether unilateral late blindness alters the peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), central macular thickness (CMT) and choroidal thickness (CT).
Methods: The 17 healthy eyes of 17 monocular patients with late blindness due to isolated eye trauma in one eye and the 19 eyes of 19 healthy individuals were evaluated in this retrospective study. Patients with at least 10 years of monocular blindness, a refractive error between + 1.5 and -1.5 D in the sighted eye, a best-corrected visual acuity of at least 20/20 and an axial length (AL) < 25 mm were included in the study. Following ophthalmologic examination, the RNFL, GCC, CMT and CT values were measured with spectral domain optic tomography (SD-OCT). Those with ocular, systemic or neurological disease that could influence the measured parameters were excluded from the study.
Results: A total of 17 (14 males, 3 females) monocular patients [mean age 41.00 ± 11.95 (24-64)] and 19 (16 males, 3 females) healthy individuals [mean age 39.79 ± 6.74 (30-56)], similar in age and gender (p = 0.949 and p = 0.881), were included in the study. The mean duration of being monocular was 22.76 ± 11.76 (10-49) years. No difference was present between the RNFL, GCC, CMT and CT measurements of the monocular patients and the healthy individuals (p = 0.692, p = 0.294, p = 0.113, p = 0.623, respectively). No significant correlation was found between the duration of monocularity and the retinal and optic nerve parameters.
Conclusion: The results of our study indicate no difference in the optic nerve, retina and choroid OCT findings in the sighted eyes of subjects with long-term monocular blindness compared to subjects with bilateral normal eyes. Although functional and volumetric neuroimaging studies suggest the possibility of compensation in these patients, our findings indicate that this is not at the ocular level.
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http://dx.doi.org/10.1007/s10792-021-01981-0 | DOI Listing |
Epilepsy Behav Rep
October 2024
Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.
This case series describes the clinical features, diagnostic challenges, treatment approaches, and outcomes of three adult patients with COQ8A-related CoQ10 deficiency presenting with focal status epilepticus, who were effectively treated at the Department of Neurology, Philipps University Marburg, Marburg, Germany. The patients, all from consanguineous families with the first two being siblings, presented with a late onset of the disease, characterized by progressive cerebellar ataxia and epilepsy, with clinical deterioration and focal status epilepticus occurring in adulthood. The first patient exhibited myoclonic status, while the second and third patients presented with bilateral tonic-clonic seizures followed by focal status epilepticus manifesting with cortical blindness.
View Article and Find Full Text PDFOphthalmol Retina
December 2024
Byers Eye Institute, Horngren Family Vitreoretinal Center, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, USA; Department of Ophthalmology, Palo Alto Medical Foundation, Palo Alto, CA, USA. Electronic address:
Objective: Evaluate the risk of age-related macular degeneration (AMD) development and progression in individuals with diagnosed obstructive sleep apnea (OSA).
Design: Retrospective cohort study.
Subjects: 60,652 and 1,173,723 individuals with OSA or not, respectively, were included in the study before propensity score matching (PSM).
Eur J Rheumatol
September 2024
Department of Rheumatology, Hospital Universitari Bellvitge, Universitat de Barcelona (UB), L'Hospitalet de LLobregat, Barcelona, Spain.
Acta Ophthalmol
November 2024
Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
Purpose: To quantify ellipsoid zone (EZ) loss during anti-VEGF therapy for neovascular age-related macular degeneration (nAMD) and correlate these findings with nAMD disease activity using artificial intelligence-based algorithms.
Methods: Spectral domain optical coherence tomography (Spectralis, Heidelberg Engineering) images from nAMD treatment-naïve patients from the Fight Retinal Blindness! (FRB!) Registry from Zürich, Switzerland were processed at baseline and over 3 years of follow-up. An approved deep learning algorithm (Fluid Monitor, RetInSight) was used to automatically quantify intraretinal fluid (IRF), subretinal fluid (SRF) and pigment epithelial detachment (PED).
Adv Gerontol
November 2024
Medical Association FEB RAS, 95 Kirova str., Vladivostok 690022, Russian Federation.
Along with increasing life expectancy and aging of the population, there is an increase in the incidence of age-related macular degeneration (AMD), which often leads to blindness or irreversible vision loss and has a pronounced impact on the quality of life. Application of an extended complex of diagnostic techniques in ophthalmologic practice in order to expand the possibilities of early diagnosis and prognosis of the disease is urgent. Screening examination of patients with AMD was carried out.
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