Purpose: Total Variation (TV) minimization algorithm is a classical compressed sensing (CS) based iterative image reconstruction algorithm that can accurately reconstruct images from sparse-view projections in computed tomography (CT). However, the system matrix used in the algorithm is often too large to be stored in computer memory. The purpose of this study is to investigate a new TV algorithm based on image rotation and without system matrix to avoid the memory requirement of system matrix.
Methods: Without loss of generality, a rotation-based adaptive steepest descent-projection onto convex sets (R-ASD-POCS) algorithm is proposed and tested to solve the TV model in parallel beam CT. Specifically, simulation experiments are performed via the Shepp-Logan, FORBILD and real CT image phantoms are used to verify the inverse-crime capability of the algorithm and evaluate the sparse reconstruction capability and the noise suppression performance of the algorithm.
Results: Experimental results show that the algorithm can achieve inverse-crime, accurate sparse reconstruction and thus accurately reconstruct images from noisy projections. Compared with the classical ASD-POCS algorithm, the new algorithm may yield the similar image reconstruction accuracy without use of the huge system matrix, which saves the computational memory space significantly. Additionally, the results also show that R-ASD-POCS algorithm is faster than ASD-POCS.
Conclusions: The proposed new algorithm can effectively solve the problem of using huge memory in large scale and iterative image reconstruction. Integrating with ASD-POCS frame, this no-system-matrix based scheme may be readily extended and applied to any iterative image reconstructions.
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http://dx.doi.org/10.3233/XST-210929 | DOI Listing |
Stem Cells
January 2025
Bioengineering Graduate Program, University of Notre Dame, Notre Dame, 46556 IN, USA.
Myocardial infarction can lead to the loss of billions of cardiomyocytes, and while cell-based therapies are an option, immature nature of in vitro-generated human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iCMs) is a roadblock to their development. Existing iPSC differentiation protocols don't go beyond producing fetal iCMs. Recently, adult extracellular matrix (ECM) was shown to retain tissue memory and have some success driving tissue-specific differentiation in unspecified cells in various organ systems.
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January 2025
Department of Surgery, Faculty of General of Medicine, Koya University, Koya, Kurdistan Region - F.R., KOY45, Iraq.
Background: During mammalian spermatogenesis, the cytoskeleton system plays a significant role in morphological changes. Male infertility such as non-obstructive azoospermia (NOA) might be explained by studies of the cytoskeletal system during spermatogenesis.
Methods: The cytoskeleton, scaffold, and actin-binding genes were analyzed by microarray and bioinformatics (771 spermatogenic cellsgenes and 774 Sertoli cell genes).
Sci Rep
January 2025
Faculty of Art and Science, Department of Chemistry, Yıldız Technical University, 34220, İstanbul, Türkiye.
In the present study, dispersive solid phase extraction - hydride generation integrated with micro-sampling gas-liquid separator - flame atomic absorption spectrometry was proposed to determine lead in lake water samples taken in the Horseshoe Island, Antarctica. In scope of this study, microwave assisted NiFeO nanoparticles were synthesized, and the characterization of nanoparticles were carried out by FT-IR, XRD and SEM. All influential parameters of dispersive solid phase extraction and hydride generation were optimized to enhance signal intensity belonging to the analyte.
View Article and Find Full Text PDFSci Rep
January 2025
School of Biosciences, University of Nottingham, Sutton Bonington, LE12 5RD, UK.
Tropical peatlands are carbon-dense ecosystems that are significant sources of atmospheric methane (CH). Recent work has demonstrated the importance of trees as an emission pathway for CH from the peat to the atmosphere. However, there remain questions over the processes of CH production in these systems and how they relate to substrate supply.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.
The aberrant vascular response associated with tendon injury results in circulating immune cell infiltration and a chronic inflammatory feedback loop leading to poor healing outcomes. Studying this dysregulated tendon repair response in human pathophysiology has been historically challenging due to the reliance on animal models. To address this, our group developed the human tendon-on-a-chip (hToC) to model cellular interactions in the injured tendon microenvironment; however, this model lacked the key element of physiological flow in the vascular compartment.
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