Objective: This study aimed to investigate the clinical efficacy of Nifedipine tablets plus Aspirin for hypertensive disorder complicating pregnancy and the effect on coagulation function and hemorheology.
Methods: A retrospective analysis of the clinical data from 108 patients with gestational hypertension hospitalized between March 2016 and March 2017 was carried out. These patients were randomly assigned into a research group and a control group, with 54 patients in each group. Patients were treated with Aspirin in the control group, and the combination of Nifedipine tablets and Aspirin in the research group so as to compare the clinical efficacy and the effect on coagulation function and hemorheology after therapy. Albumin, total protein, 24-hour urinary protein and mean arterial pressure (MAP) were observed and compared between the two groups.
Results: The overall effective rate of treatment in the research group was significantly higher than that in the control group (P < 0.05). The prothrombin time (PT) and fibrinogen (FIB) levels were markedly superior to those before therapy in the research group (P < 0.001), and the PT and FIB after treatment were remarkably better in the research group than in the control group (P < 0.001). The levels of plasma viscosity (PV), low-shear whole blood viscosity (LBV), and high-shear whole blood viscosity (HBV) after therapy were markedly reduced than before therapy in the two groups (P < 0.05), and the levels of PV, LBV, and HBV after therapy were significantly lower in the research group than those in the control group (P < 0.05). Adverse reactions after therapy were reported at a significantly lower incidence in the research group than the control group (P < 0.05). Adverse pregnancy outcomes were reported at a significantly lower incidence in the research group than in the control group (P < 0.05). The research group significantly outperformed the control group on Albumin, total protein, 24-hour urinary protein and mean arterial pressure (P < 0.05).
Conclusion: Nifedipine tablets plus Aspirin for patients with gestational hypertension can effectively improve coagulation function and hemorheological parameters, with high safety.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290755 | PMC |
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