Periodontal tissue regeneration combined with orthodontic treatment can improve clinical efficacy and periodontal function of patients with periodontitis.

Objective: To determine the efficacy of periodontal tissue regeneration (PTR) combined with orthodontic treatment in patients with periodontitis.

Methods: A total of 118 patients with periodontitis admitted to our hospital between March 2017 and May 2019 were enrolled. Among them, 56 patients were treated with PTR as a regular group, while the rest 62 were treated with PTR combined with orthodontic treatment as a joint group. The two groups were compared in efficacy, total treatment time, recovery time for periodontal function, periodontal function-associated indexes before and after treatment, pain, serum inflammatory factors, adverse reactions, and treatment satisfaction.

Results: The joint group showed significantly higher effective treatment rate (<0.05), and experienced significantly shorter total treatment time and recovery time for periodontal function than the regular group (both <0.05). Before treatment, there was no meaningful difference between the two groups in plaque index (PLI), periodontal pocket probing depth (PD), sulcus bleeding index (SBI), attachment loss (AL), visual analog scale (VAS) score, and serum IL-6, IL-1β and TNF-α levels, while after treatment, these indexes of both groups improved (all <0.05), and the improvement in the joint group was more notable (<0.05). Additionally, there were no significant difference between the two groups in the incidence of adverse reactions (>0.05), and the joint group expressed significantly higher treatment satisfaction (<0.05).

Conclusion: With a high safety, PTR combined with orthodontic treatment can effectively alleviate the clinical symptoms of patients and promote the recovery of their periodontal function, and is more acceptable, so it is worthy of clinical promotion.