Tyrosinase Inhibitors from the Stems of .

Evid Based Complement Alternat Med

Faculty of Chemistry, University of Science, 227 Nguyen Van Cu Street, Ward 4, District 5, Ho Chi Minh City, Vietnam.

Published: July 2021

Two new stilbene derivatives, named strebluses C and D, were isolated from the EtOAc-soluble fraction of the stems of (Moraceae). Its absolute configuration was elucidated based on NMR spectroscopic data interpretation and optical rotation calculation. Streblus C possesses strong tyrosinase inhibitory activity with an IC value of 0.01 M. Docking studies of and with -tyrosinase were carried out to analyze their interactions. The analysis of the docked poses confirmed that showed better binding affinity for -tyrosinase than that of .

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266447PMC
http://dx.doi.org/10.1155/2021/5561176DOI Listing

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