Microbiology and Immunology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Published: June 2021
AI Article Synopsis
Article Abstract
() plays a crucial role in the pathogenesis of gastritis, peptic ulcer, and gastric cancer. The presence of pathogenicity islands (PAI) genes contributes to the pathogenesis of many gastrointestinal disorders. Cytotoxin-associated gene A () and vacuolating cytotoxin gene () are the most known virulence genes in . So, our aim was to study virulence genes' role in gastric disorders pathogenesis. Our study included 150 adult patients who suffered dyspeptic symptoms and were referred to the GIT endoscopy unit. Gastric biopsies were attained for rapid urease test (RUT) and histopathological examination, and multiplex PCR technique for detection of virulence genes was performed. It was found that 100 specimens were (RUT) positive, of which sixty samples (60%) were PCR positive for gene. The and genes were identified in 61.6% and 53% of strains, respectively. Only 5 cases were -positive and -negative. The most virulent s1 allele existed in 56.6% of cases. Out of the 60 strains, 66% had at least one virulence gene and 34% did not show any virulence gene. infection showed significant increase with age. are prevalent amid dyspeptic patients in our region. The main genotype combinations were +/+ of genotype and they were frequently associated with peptic ulcer diseases, gastritis, and gastroesophageal reflux disease.
Background: Previous research has demonstrated correlations between the complex types and functions of brain cells and the etiology of glioma. However, the causal relationship between gene expression regulation in specific brain cell types and glioma risk, along with its therapeutic implications, remains underexplored.
Methods: Utilizing brain cell type-specific cis-expression quantitative trait loci (cis-eQTLs) and glioma genome-wide association study (GWAS) datasets in conjunction with Mendelian randomization (MR) and colocalization analyses, we conducted a systematic investigation to determine whether an association exists between the gene expression of specific brain cell types and the susceptibility to glioma, including its subtypes.
Avian pathogenic Escherichia coli (APEC) is a significant cause of worldwide morbidity, mortality, and production loss in the poultry industry. Here, we characterized 115 E. coli isolates from avian-diagnosed colibacillosis cases from Georgia, USA in 2022 as part of a year two follow on surveillance using both current and a newly developed serogrouping tool (Klao9-SeroPCR).
Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry of Agriculture and Rural Affairs), Hubei Provincial Key Laboratory of Animal Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan 430064, China. Electronic address:
Pigeon has become popular as a food recently, due to their highly nutritive valuE. colibacillosis, which is caused by pathogenic E. coli, is one of the most important bacterial diseases in pigeon breeding.
Dioscorea alata, a key tuber crop for global food security, is threatened by anthracnose disease caused by Colletotrichum gloeosporioides. However, identification of functional resistance genes against C. gloeosporioides in D.
Background: is a transmitted respiratory pathogen that causes high morbidity and mortality in children, especially those under 5 years of age. During the implementation of population control measures for COVID-19 in mainland China, the detection rate in pediatric patients decreased. However, with the second wave of the COVID-19 pandemic (2022), the incidence of pneumococcal disease (PD) and even invasive pneumococcal disease (IPD) began to rise again.
