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The Differential Growth Inhibition of spp. Caused by the Rare Sugar Tagatose Is Associated With Species-Specific Metabolic and Transcriptional Changes. | LitMetric

AI Article Synopsis

Article Abstract

Tagatose is a rare sugar with no negative impacts on human health and selective inhibitory effects on plant-associated microorganisms. Tagatose inhibited mycelial growth and negatively affected mitochondrial processes in , but not in . The aim of this study was to elucidate metabolic changes and transcriptional reprogramming activated by and in response to tagatose, in order to clarify the differential inhibitory mechanisms of tagatose and the species-specific reactions to this rare sugar. and activated distinct metabolic and transcriptional changes in response to the rare sugar. Tagatose negatively affected mycelial growth, sugar content and amino acid content in with a severe transcriptional reprogramming that included the downregulation of genes involved in transport, sugar metabolism, signal transduction, and growth-related process. Conversely, tagatose incubation upregulated genes related to transport, energy metabolism, sugar metabolism and oxidative stress in with no negative effects on mycelial growth, sugar content and amino acid content. Differential inhibitory effects of tagatose on spp. were associated with an attempted reaction of , which was not sufficient to attenuate the negative impacts of the rare sugar and with an efficient response of with the reprogramming of multiple metabolic processes, such as genes related to glucose transport, pentose metabolism, tricarboxylic acid cycle, reactive oxygen species detoxification, mitochondrial and alternative respiration processes. Knowledge on the differential response of spp. to tagatose represent a step forward in the understanding functional roles of rare sugars.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292896PMC
http://dx.doi.org/10.3389/fmicb.2021.711545DOI Listing

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