Introduction: The expression of specific miRNAs and their mRNA targets are changed in infectious disease. The aim of this study was to analyze the expression of pro-neuroinflammatory miRNAs, anti-neuroinflammatory miRNAs, and their mRNA targets in the serum of COVID-19 patients with different grades.
Methods: COVID-19 patients with different grades were enrolled in this study and the expression of pro-neuroinflammatory miRNAs, anti-neuroinflammatory miRNAs, and their target mRNAs was analyzed by q-PCR.
Results: The relative expression of anti- neuroinflammatory miRNAs (, , and ) was decreased and the relative expression of their target mRNAs (, , and ) was increased. Also, the relative expression of pro-neuroinflammatory miRNAs (, , and ) was increased and the relative expression of their target mRNA (, , and ) was decreased in COVID-19 patients with increase of disease grade. A negative significant correlation was seen between and mRNA, and mRNA, and mRNA, and mRNA, and mRNA, and between and mRNA in COVID-19 patients ( < 0.05).
Conclusions: This study showed that the relative expression of anti- neuroinflammatory miRNAs was decreased and the relative expression of their targeted mRNAs was increased in COVID-19 patients from asymptomatic to critical illness. Also, this study showed that the relative expression of pro-neuroinflammatory miRNAs was increased and the relative expression of their targeted mRNA was decreased in COVID-19 patients from asymptomatic to critical illness.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282440 | PMC |
| http://dx.doi.org/10.1016/j.nrl.2021.06.005 | DOI Listing |
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