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| http://dx.doi.org/10.1007/s00415-021-10707-2 | DOI Listing |
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Circulating Liquid Biopsy Biomarkers in Glioblastoma: Advances and Challenges.
Int J Mol Sci
July 2024
Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.
Gliomas, particularly glioblastoma (GBM), represent the most prevalent and aggressive tumors of the central nervous system (CNS). Despite recent treatment advancements, patient survival rates remain low. The diagnosis of GBM traditionally relies on neuroimaging methods such as magnetic resonance imaging (MRI) or computed tomography (CT) scans and postoperative confirmation via histopathological and molecular analysis.
View Article and Find Full Text PDFPericytes Are Immunoregulatory Cells in Glioma Genesis and Progression.
Int J Mol Sci
May 2024
Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, Excellence Center Severo Ochoa, Campus de San Juan, Avda. Ramón y Cajal sn, 03550 Alicante, Spain.
Vascular co-option is a consequence of the direct interaction between perivascular cells, known as pericytes (PCs), and glioblastoma multiforme (GBM) cells (GBMcs). This process is essential for inducing changes in the pericytes' anti-tumoral and immunoreactive phenotypes. Starting from the initial stages of carcinogenesis in GBM, PCs conditioned by GBMcs undergo proliferation, acquire a pro-tumoral and immunosuppressive phenotype by expressing and secreting immunosuppressive molecules, and significantly hinder the activation of T cells, thereby facilitating tumor growth.
View Article and Find Full Text PDFConcept of a fully-implantable system to monitor tumor recurrence.
Sci Rep
September 2023
Department of Neurosurgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, 40225, Düsseldorf, Germany.
Current treatment for glioblastoma includes tumor resection followed by radiation, chemotherapy, and periodic post-operative examinations. Despite combination therapies, patients face a poor prognosis and eventual recurrence, which often occurs at the resection site. With standard MRI imaging surveillance, histologic changes may be overlooked or misinterpreted, leading to erroneous conclusions about the course of adjuvant therapy and subsequent interventions.
View Article and Find Full Text PDFCase Report: Brain tumor's pitfalls: two cases of high-grade brain tumors mimicking autoimmune encephalitis with positive onconeuronal antibodies.
Front Oncol
August 2023
Department of Neuroscience, Imaging and Clinical Science, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Article Synopsis
- Glioblastoma (GBM) is a serious type of brain tumor that can be confused with another illness called autoimmune encephalitis (AE).* ! Two patients with high-grade brain tumors were first treated for AE, showing how easy it is to mix them up in diagnosis.* ! Doctors should be careful with certain brain scan results and tests because they can lead to delays in proper treatment, and a brain biopsy is often needed to confirm if it's GBM.
Analysis of Functional Neuroplastic Changes in the Cortical Language System in Relation to Different Growth Patterns of Glioblastoma.
Brain Sci
May 2023
Department of Neurosurgery, University Hospital Regensburg, 93053 Regensburg, Germany.
The interpretation of fMRI data in glioblastoma (GB) is challenging as these tumors exhibit specific hemodynamic processes which, together with malignancy, tumor volume and proximity to eloquent cortex areas, may lead to misinterpretations of fMRI signals. The aim of this study was to investigate if different radiologically defined GB tumor growth patterns may also influence the fMRI signal, activation pattern and functional connectivity differently. Sixty-four patients with left-hemispheric glioblastoma were included and stratified according to their radiologically defined tumor growth pattern into groups with a uniform (U-TGP) or diffuse tumor growth pattern (D-TGP).
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