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Critical appraisal of the contemporary use of atherectomy to treat femoropopliteal atherosclerotic disease. | LitMetric

Critical appraisal of the contemporary use of atherectomy to treat femoropopliteal atherosclerotic disease.

J Vasc Surg

Division of Vascular and Endovascular Surgery, University of Colorado, Anschutz Medical Center, Aurora, Colo. Electronic address:

Published: February 2022

AI Article Synopsis

  • - The objective of the study was to systematically review and analyze the effectiveness and complications of atherectomy for treating femoropopliteal atherosclerotic disease, amid ongoing debates about its use.
  • - Researchers analyzed data from 24 studies involving 1900 patients, focusing on treatment outcomes like patency rates and associated morbidities after atherectomy, which included various techniques like directional, rotational, laser, and orbital atherectomy.
  • - Results showed a high technical success rate (92.3%) and an initial patency rate of 95.4%, but a drop to 72.6% at 12 months, with some patients experiencing complications like distal embolization and vessel perforation. *

Article Abstract

Objective: Atherectomy has become increasingly used as an endovascular treatment of lower extremity atherosclerotic disease in the United States. However, concerns and controversies about its indications and outcomes exist. The goal of the present systematic review and meta-analysis was to investigate the outcomes and complications related to atherectomy to treat femoropopliteal atherosclerotic disease.

Methods: A systematic review in accordance with the recommendations from the PRISMA (preferred reporting items for systematic reviews and meta-analyses) statement was performed. Four major scientific repositories (MEDLINE, Embase, the Cochrane Library, and Thompson Web of Sciences) were queried from their inception to April 5, 2020. We reviewed and entered the data in a dedicated dataset. The outcomes included the patency rates, clinical and hemodynamic improvement, and morbidity and mortality associated with atherectomy interventions.

Results: Twenty-four studies encompassing 1900 patients met the inclusion criteria for the present study. Of the 1900 patients, 74.3% had presented with Rutherford class 1 to 3 and 25.7% presented with Rutherford class 4 to 6; 1445 patients had undergone atherectomy, and 455 patients had been treated without atherectomy. The atherectomy group had undergone directional atherectomy (n = 851), rotational atherectomy (n = 851), laser atherectomy (n = 201), and orbital atherectomy (n = 78). Most of these patients had also received adjunct treatments, which varied across the studies and included a combination of stenting, balloon angioplasty, or drug-coated balloon angioplasty. Technical success was achieved in 92.3% of the cases. Distal embolization, vessel perforation, and dissection occurred in 3.4%, 1.9%, and 4% of the cases, respectively. The initial patency was 95.4%. At the 12-month median follow-up, the primary patency was 72.6%. The ankle brachial index had improved from a preoperative mean of 0.6 to a postoperative mean of 0.84. The incidence of major amputation and mortality during the follow-up period was 2.2% and 3.4%, respectively.

Conclusions: The results from our review of the reported data suggest that femoropopliteal atherectomy can be completed safely, modestly improving the ankle brachial index and maintaining the 1-year patency in nearly three of four patients. However, these findings were based on heterogeneous studies that skewed the generalizable conclusions about atherectomy's efficacy. Atherectomy places a high cost burden on the healthcare system and is used in the United States at a higher rate than in other countries. Our review of the literature did not demonstrate clear atherectomy superiority to alternatives that would warrant the pervasive and increasing use of this costly technology. Future work should focus on developing high-quality randomized controlled trials to determine the specific patient and lesion characteristics for which atherectomy can add value.

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Source
http://dx.doi.org/10.1016/j.jvs.2021.07.106DOI Listing

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