Aquaporins: New markers for male (in)fertility in livestock and poultry?

Improving the methods utilized to facilitate reproduction is associated with a constant need to search for new factors that not only significantly affect reproductive processes, but also create new possibilities when assessing male reproductive potential. Aquaporins (AQPs) belong to a family of small (28-30 kDa) proteins that facilitate the transport of water and other small molecules. There have been 13 AQPs (AQP0-AQP12) discovered in mammals, and these proteins are present in a wide range of cell types. Almost all AQPs, except AQP6 and AQP12 are present in the male reproductive organs and sperm of mammals and birds. Increasing evidence suggests that these proteins are involved in a number of processes responsible for the optimal functioning of the male reproductive system. This review presents the current state of knowledge regarding the abundance and distribution of AQPs in the male reproductive organs and sperm of various livestock and poultry species, including buffalo, cattle, sheep, horses, pigs, turkeys and goose. Furthermore, the possible physiological and pathophysiological significance of AQPs in male reproduction, as well as hormonal regulation of quantities are discussed. It can be concluded from the studies analyzed in this paper that abundance patterns of AQPs may be considered in the future as specific and universal biomarkers of male fertility and infertility in animal husbandry.