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| http://dx.doi.org/10.1073/pnas.2026345118 | DOI Listing |
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Highly Efficient Compositional and Compound Specific Isotopic Analysis of Volatile Primary Amines and Ammonia in the Murchison Meteorite Using SPME On-Fiber Derivatization: Optimization for Bennu Sample Analyses.
Rapid Commun Mass Spectrom
April 2025
Solar System Exploration Division, NASA Goddard Space Center, Greenbelt, Maryland, USA.
Rationale: Extraterrestrial amines and ammonia are critical ingredients for the formation of astrobiologically important compounds such as amino acids and nucleobases. However, conventional methods for analyzing the composition and isotopic ratios of volatile amines suffer from lengthy derivatization and purification procedures, high sample mass consumption, and chromatographic interferences from derivatization reagents and non-target compounds.
Methods: Here we demonstrate a highly efficient method to analyze the composition and compound specific isotopic ratios of C to C amines as well as ammonia based on solid phase micro-extraction (SPME) on-fiber derivatization.
Pharmacokinetics, mass balance, and metabolism of [C]PLB1004, a selective and irreversible EGFR-TKI in humans.
Cancer Chemother Pharmacol
January 2025
Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, 250014, China.
Purpose: PLB1004, developed by Beijing Avistone Biotechnology Co., Ltd., is a safe, highly selective, and efficient irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) employed in treating non-small-cell-lung-cancer (NSCLC).
View Article and Find Full Text PDFUtility of quantitative whole-body autoradiography (QWBA) and oxidative combustion (OC) analysis in the assessment of tissue distribution of [14C]Mefuparib (CVL218) in SD and LE rats.
PLoS One
December 2024
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.
Background: In tissue distribution studies of radiopharmaceuticals, quantitative whole-body autoradiography (QWBA) and oxidative combustion (OC) analysis are the two important methods that have not been compared using the same drug. Sprague-Dawley (SD) and Long-Evans (LE) rats, both of which are commonly used rodents in tissue distribution studies, have also not been compared using the same drug. Comparative studies are important for aiding the selection of appropriate experimental methods and animals.
View Article and Find Full Text PDFStudy on the dynamics of radon concentration buildup in the closed-loop measurement system with RAD7 online radon monitor.
Radiat Prot Dosimetry
December 2024
Environmental Assessment Division, Indira Gandhi Center for Atomic Research, Kalpakkam, Chengalpattu District, Tamilnadu 603102, India.
Article Synopsis
- The study assesses radon and thoron exhalation rates using a closed-loop technique with online radon monitors, particularly focusing on the balance of air volume in the sample and detector chambers.
- An alternative model is proposed that treats the sample and detector chambers as separate entities, refining the mass balance equation to account for air flow rates affecting radon/thoron concentrations.
- Results indicate that while lower flow rates don't affect long-lived radon buildup, experiments showed that increasing flow rates impacts the effective removal rate of radon, suggesting potential issues with thoron interference at lower flows.
Magnitude and timescales of Ca isotope variability in human urine: implications for bone mass balance monitoring.
Metallomics
November 2024
The Isotoparium, Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125, United States.
Calcium (Ca) isotopes in blood/urine are emerging biomarkers of bone mineral balance (BMB) in the human body. While multiple studies have investigated Ca isotopes in patients suffering from diseases affecting BMB, comparatively little effort has been devoted to understanding the homeostasis of Ca isotopes in healthy individuals. Here, we report on a longitudinal study of the urine Ca isotope composition (δ44/42CaUrine) from 22 healthy participants (age 19-60) over timescales ranging from days to months.
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