AI Article Synopsis

  • The study examines treatment options for locoregional recurrent head and neck squamous cell cancer (HNSCC), focusing on two strategies: platinum-based chemotherapy with cetuximab and re-radiotherapy with cetuximab.* -
  • A total of 192 patients were analyzed, revealing that those receiving re-radiotherapy had better progression-free survival (9.2 months) and overall survival (12.8 months) compared to those who underwent chemotherapy (5.1 months and 7.9 months, respectively).* -
  • The findings suggest that combining radiotherapy with cetuximab offers improved survival outcomes over chemotherapy plus cetuximab for patients with local recurrence of HNSCC.*

Article Abstract

Treatment options of locoregional recurrent head and neck squamous cell cancer (HNSCC) include both local strategies as surgery or re-radiotherapy and systemic therapy. In this prospective, multi-center, non-interventional study, patients were treated either with platinum-based chemotherapy and cetuximab (CT + Cet) or re-radiotherapy and cetuximab (RT + Cet). In the current analysis, progression-free survival (PFS) and overall survival (OS) were compared in patients with locoregional recurrence. Four hundred seventy patients were registered in 97 German centers. After exclusion of patients with distant metastases, a cohort of 192 patients was analyzed (129 CT + Cet, 63 RT + Cet). Radiotherapy was delivered as re-irradiation to 70% of the patients. The mean radiation dose was 51.8 Gy, whereas a radiation dose of ≥60 Gy was delivered in 33% of the patients. Chemotherapy mainly consisted of cisplatin/5-flurouracil (40%) or carboplatin/5-flurouracil (29%). The median PFS was 9.2 months in the RT + Cet group versus 5.1 months in the CT + Cet group (hazard ratio for disease progression or death, 0.40, 95% CI, 0.27-0.57, < 0.0001). Median OS was 12.8 months in the RT + Cet group versus 7.9 months in the CT + Cet group (hazard ratio for death, 0.50, 95% CI, 0.33-0.75, = 0.0008). In conclusion, radiotherapy combined with cetuximab improved survival compared to chemotherapy combined with cetuximab in locally recurrent HNSCC.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305667PMC
http://dx.doi.org/10.3390/cancers13143413DOI Listing

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