AI Article Synopsis
- Many therapeutic agents fail in clinical development due to toxic effects on healthy tissues, prompting the use of nanotechnology to improve drug delivery.
- Biodegradable and biocompatible polymers are highlighted as effective materials for creating polymeric nanoparticles, which enhance drug targeting and circulation time.
- The text discusses various applications of polymeric nanoparticles in cancer treatment, covering their materials, formulation methods, mechanisms, and ongoing clinical research.
Article Abstract
Many therapeutic agents have failed in their clinical development, due to the toxic effects associated with non-transformed tissues. In this context, nanotechnology has been exploited to overcome such limitations, and also improve navigation across biological barriers. Amongst the many materials used in nanomedicine, with promising properties as therapeutic carriers, the following one stands out: biodegradable and biocompatible polymers. Polymeric nanoparticles are ideal candidates for drug delivery, given the versatility of raw materials and their feasibility in large-scale production. Furthermore, polymeric nanoparticles show great potential for easy surface modifications to optimize pharmacokinetics, including the half-life in circulation and targeted tissue delivery. Herein, we provide an overview of the current applications of polymeric nanoparticles as platforms in the development of novel nanomedicines for cancer treatment. In particular, we will focus on the raw materials that are widely used for polymeric nanoparticle generation, current methods for formulation, mechanism of action, and clinical investigations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304499 | PMC |
| http://dx.doi.org/10.3390/cancers13143387 | DOI Listing |
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