Extracting the chemical-induced disease relation from literatures is important for biomedical research. On one hand, it is challenging to capture the interactions among remote words and the long-distance information is not adequately exploited by existing systems for document-level relation extraction. On the other hand, there is some information particularly important to the target relations in documents, which should attract more attention than the less relevant information for the relation extraction. However, this issue is not well addressed in existing methods. In this paper, we present a method that integrates a hybrid graph and a hierarchical concentrative attention to overcome these problems. The hybrid graph is constructed by synthesizing the syntactic graph and Abstract Meaning Representation graph to acquire the long-distance information for document-level relation extraction. Meanwhile, the concentrative attention is used to focus on the most important information, and alleviate the disturbance brought by the less relevant items in the document. The experimental results demonstrate that our model yields competitive performance on the dataset of chemical-induced disease relations.
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http://dx.doi.org/10.1016/j.jbi.2021.103874 | DOI Listing |
DNA Cell Biol
January 2025
Research Center of Integrated Traditional Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou 646000, China.
Liver fibrosis, one of the main histological determinants of various chronic liver diseases, currently lacks effective treatment. Hepatic stellate cells (HSCs) are pivotal in the production of extracellular matrix and amplify the fibrogenic response. Inhibiting the activation of HSCs or promoting the senescence of activated HSCs is crucial for the regression of liver fibrosis.
View Article and Find Full Text PDFCell Chem Biol
December 2024
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:
Chemical inducers of proximity (CIPs) are molecules that recruit one protein to another and introduce new functionalities toward modulating protein states and activities. While CIP-mediated recruitment of E3 ligases is widely exploited for the development of degraders, other therapeutic modalities remain underexplored. We describe a non-degrader CIP-DNA-encoded library (CIP-DEL) that recruits FKBP12 to target proteins using non-traditional acyclic structures, with an emphasis on introducing stereochemically diverse and rigid connectors to attach the combinatorial library.
View Article and Find Full Text PDFWound Repair Regen
December 2024
Department of Zoology, Trivenidevi Bhalotia College, Raniganj, West Bengal, India.
Hypoxia-mediated cardiac tissue injury and its repair or regeneration are one of the major health management challenges globally. Unlike mammals, lower vertebrate species such as zebrafish (Danio rerio) represent a natural model to study cardiac injury, repair and regeneration. Thyroxine (T3) has been hypothesised to be one of the endocrine factors responsible for the evolutionary trade-off for acquiring endothermy and regenerative capability in higher vertebrates.
View Article and Find Full Text PDFToxicology
December 2024
Department of Environmental Health, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing 400038, China; Institute of Toxicology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing 400038, China. Electronic address:
Polycyclic aromatic hydrocarbons (PAHs) are important environmental carcinogens that can cause lung cancer. However, the underlying epigenetic mechanism during PAHs-induced lung carcinogenesis has remained largely unknown. Previously, we screened some novel epigenetic regulatory genes during 3-methylcholanthrene (3-MCA)-induced lung carcinogenesis, including the potassium inwardly rectifying channel subfamily J member 15 (KCNJ15) gene.
View Article and Find Full Text PDFClin Cosmet Investig Dermatol
November 2024
Research, Vantage, Warren, NJ, USA.
Introduction: It is well established that () is a common skin commensal microorganism that has been linked to acne. In acne flare-ups, can be found in abundant levels within the inflammatory lesions (called comedones) associated with the skin disease. Recently, it was reported that 3D reconstructed human epidermis (RHE) treated with viable cultures of can elicit β-defensin antimicrobial peptide responses in the skin and can weaken the skin barrier of the RHE after three days of exposure to .
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