Scientists have long been fascinated by the complexity of eukaryotic transcription and the large numbers of proteins involved at each step in the process. In this issue of Cell, Schilbach et al. bring us one important step closer to the goal of a complete understanding of transcription at atomic resolution.
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Post-Telemedicine Acute Care for Undifferentiated High-Acuity Conditions: Is a Picture Worth a Thousand Words?
Telemed J E Health
January 2025
Kaiser Permanente Division of Research, Pleasanton, California, USA.
Telemedicine use increased substantially with the COVID-19 pandemic. Understanding of the impact of telemedicine modality (video vs. phone) on post-telemedicine acute care for higher risk conditions is limited.
View Article and Find Full Text PDFIs the shift in treatment patterns towards new, more expensive drugs still driving the increase in pharmaceutical expenditure? A decomposition analysis of expenditure data in Sweden 1990-2022.
Expert Rev Pharmacoecon Outcomes Res
December 2024
Health Economics Unit, Department of Clinical Science (Malmö), Lund University, Lund, Sweden.
Background: Pharmaceutical expenditures (PE) are increasing worldwide, raising concerns about sustainability. However, the current price index provides an incomplete picture of this trend due to the rapid introduction of new drugs on the market.
Objective: The aim of this study is to decompose PE into their components and investigate the development in Sweden from 1990 to 2022.
Diaphragm ultrasonography: A picture is worth a thousand words.
Exp Physiol
December 2024
Department of Physiology, University College Cork, Cork, Ireland.
Is a picture worth the same emotions everywhere? Validation of images from the Nencki affective picture system in Malaysia.
Discov Ment Health
December 2024
Department of Economics, University of Warwick, Coventry, UK.
Several validated image sets, such as NAPS, IAPS, GAPED, and OASIS, have been developed to elicit affective states. However, these image sets were primarily validated on Western populations within European and American contexts, and none have been fully validated in a Southeast Asian sample, where emotional restraint may also be valued similarly to the East Asian contexts. This study aimed to validate and provide norms for the Nencki Affective Picture System (NAPS; Marchewka et al.
View Article and Find Full Text PDFA Picture is Worth a Thousand Timesteps: Excess Entropy Scaling for Rapid Estimation of Diffusion Coefficients in Molecular-Dynamics Simulations of Fluids.
J Chem Theory Comput
December 2024
Department of Civil and Environmental Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, United States.
In molecular-dynamics simulations of fluids, the Einstein-Helfand (EH) and Green-Kubo (GK) relationships are frequently used to compute a variety of transport coefficients, including diffusion coefficients. These relationships are formally valid in the limit of infinite sampling time: The error in the estimate of a transport coefficient (relative to an infinitely long simulation) asymptotically approaches zero as more dynamics are simulated and recorded. In practice, of course, one can only simulate a finite number of particles for a finite amount of time.
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