Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1001/jamainternmed.2021.4237 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
First and Second Degree Left Bundle Branch Block and Masquerading Bundle Branch Block: Lessons Learned During Conduction System Pacing.
Heart Rhythm
January 2025
Geisinger Heart Institute, Geisinger Wyoming Valley Medical Center, MC 36-10, 1000 E Mountain Blvd, Wilkes-Barre, PA 18711.
COVID-19: Lessons Learned from Molecular and Clinical Research.
Int J Mol Sci
January 2025
IRCAD (Interdisciplinary Research Center of Autoimmune Diseases), Università del Piemonte Orientale (UPO), 28100 Novara, Italy.
SARS-CoV-2 virus, the etiological agent of the novel coronavirus disease 19 (COVID-19), was first identified in late 2019, following the sudden appearance of a cluster of pneumonia cases of unknown origin in China [...
View Article and Find Full Text PDFLessons from Deep Learning Structural Prediction of Multistate Multidomain Proteins-The Case Study of Coiled-Coil NOD-like Receptors.
Int J Mol Sci
January 2025
Department of Bioinformatics and Structural Biochemistry, Institute of Biochemistry of the Romanian Academy, Splaiul Independentei 296, 060031 Bucharest, Romania.
We test here the prediction capabilities of the new generation of deep learning predictors in the more challenging situation of multistate multidomain proteins by using as a case study a coiled-coil family of Nucleotide-binding Oligomerization Domain-like (NOD-like) receptors from and a few extra examples for reference. Results reveal a truly remarkable ability of these platforms to correctly predict the 3D structure of modules that fold in well-established topologies. A lower performance is noticed in modeling morphing regions of these proteins, such as the coiled coils.
View Article and Find Full Text PDFThe Role of the Tumor Microenvironment in T-Cell Redirecting Therapies of Large B-Cell Lymphoma: Lessons Learned from CAR-T to Bispecific Antibodies.
Cancers (Basel)
January 2025
RM Gorbacheva Research Institute of Pediatric Oncology, Hematology and Transplantation, Pavlov University, 191144 St. Petersburg, Russia.
T-cell redirecting therapies, which include chimeric antigen receptor T-cells (CAR-Ts) and bispecific antibodies (BSAs), have revolutionized the treatment of relapsed\refractory large B-cell lymphoma (LBCL). Expanding clinical experience with these advanced therapies shows the potential for the optimization of their use with combination or consolidation strategies, which necessitates the prognostic stratification of patients. While traditional clinical prognostic factors identified in the era of chemotherapy are characterized by limited value, the tumor microenvironment (TME) is becoming a new prognostic cluster.
View Article and Find Full Text PDFEarly COVID-19 Pandemic Preparedness: Informing Public Health Interventions and Hospital Capacity Planning Through Participatory Hybrid Simulation Modeling.
Int J Environ Res Public Health
December 2024
Department of Computer Science, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada.
We engaged with health sector stakeholders and public health professionals within the health system through a participatory modeling approach to support policy-making in the early COVID-19 pandemic in Saskatchewan, Canada. The objective was to use simulation modeling to guide the implementation of public health measures and short-term hospital capacity planning to mitigate the disease burden from March to June 2020. We developed a hybrid simulation model combining System Dynamics (SD), discrete-event simulation (DES), and agent-based modeling (ABM).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!