AI Article Synopsis
- Cerebral ischemic stroke (CIS) is a severe condition caused by the rupture of brain blood vessels, leading to significant brain damage due to reduced blood flow and oxygen.
- Betulinic acid (BA), derived from birch bark, shows protective effects against cerebral injury, which is investigated in experiments involving both live rat models and cultured cells.
- The study found that BA helps mitigate brain damage by lowering oxidative stress and activating the SIRT1/FoxO1 pathway, which inhibits autophagy and improves recovery in rats suffering from CIS.
Article Abstract
Cerebral ischemic stroke (CIS) is an acute cerebrovascular disease that is caused by the sudden rupture of blood vessels inside the brain and the intervention of reperfusion to the brain, resulting in severe cerebral injury. Autophagy has been reported to be involved in the occurrence and progression of CIS. Betulinic acid (BA) is a pentacyclic triterpene acid mainly extracted from birch bark. Studies have shown the neuroprotective effects of BA. Here, the effect and mechanism of BA on ischemia-reperfusion induced cerebral injury was explored using a CIS model in vivo via 1 h middle cerebral artery occlusion (MCAO) and 24 h reperfusion in rats and in vitro via oxygen-glucose deprivation/reperfusion (OGD/R) of PC12 cells, respectively. We found that BA not only reduced cerebral injury by reducing oxidative stress but also activated the SIRT1/FoxO1 pathway to suppress autophagy and improve cerebral injury in MCAO rats. These results provide a basis for the potential clinical application of BA.
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| http://dx.doi.org/10.1021/acschemneuro.1c00198 | DOI Listing |
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