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Similar Publications

Syphilitic Hepatitis: An Uncommon Manifestation of Secondary Syphilis.

Cureus

November 2024

Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA) Health, Los Angeles, USA.

Syphilitic hepatitis is a rare manifestation of a sexually transmitted infection. Given its nonspecific presentation, it is important for clinicians to consider the diagnosis in sexually active patients presenting with elevated liver tests.  In this case, a 30-year-old man presented with an itchy rash and was diagnosed with an allergic reaction.

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Syphilitic granulomatous hepatitis.

Clin Res Hepatol Gastroenterol

December 2024

Department of Radiology, Institut Curie Saint Cloud, 35 rue Dailly, 92210 Saint Cloud, France.

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Syphilitic hepatitis in infants, the forgotten disease that hepatologists have to brush up on: from a case series to a revision of literature.

Eur J Pediatr

November 2024

Pediatric Department for the Treatment and Study of Abdominal Diseases and Abdominal Transplantation, IRCCS ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies), University of Pittsburgh Medical Center, 90127, Palermo, Italy.

Clinical manifestations of congenital syphilis (CS) include liver disease with/without impaired liver function, identified as syphilitic hepatitis. Hepatic involvement may be dramatic; therefore, early diagnosis is crucial to provide treatment and prevent fatal outcomes. A new resurgence of CS cases has been described in recent years worldwide.

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Article Synopsis
  • - A 25-year-old patient with a history of unprotected sex developed cholestatic jaundice and severe itching for two months, leading to an examination that revealed intense jaundice and swollen lymph nodes.
  • - Imaging showed edema and lymphadenopathy, while blood tests indicated significant liver enzyme elevation and negative viral serologies, prompting further testing for syphilis, which returned positive.
  • - A liver biopsy confirmed syphilitic hepatitis, resulting in treatment with ceftriaxone, which led to remarkable improvement within 48 hours.
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Syphilitic hepatitis is a very rare presentation of syphilis infection, characterized by inflammation of the liver due to the invasion of hepatic tissue by the bacterium Treponema pallidum. This review article provides an in-depth analysis of the existing body of information pertaining to syphilitic hepatitis. The article primarily concentrates on key aspects such as the epidemiology, clinical manifestations, diagnostic methods, and therapeutic approaches associated with this condition.

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