Questions about what comes next for the coronavirus disease 2019 pandemic have been posed by the editors to everyone except those who proliferate conspiracy theories. Conspiracy theories have consequences for public health. Making these dangers known can initiate discussions on public trust. The problem is that the pressing concerns of the pandemic have enabled manufactured consent to be a suspicious thing known of the propaganda model more than ever. Although such a model can be put into question, the public must also be able to practice empathy and true choice so that asking and responding to the questions at hand considers a responsibility to public health.
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http://dx.doi.org/10.1093/pubmed/fdab300 | DOI Listing |
Rheumatol Ther
March 2025
Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Introduction: Long-term treatment of psoriatic arthritis (PsA) is required to prevent progression. However, persistence with current treatments is challenging due to tolerability and acceptability issues. The objective of this study was to estimate 1-year persistence with secukinumab in patients with PsA treated with secukinumab, to compare persistence rates between secukinumab and adalimumab, to estimate usefulness rates, and to document adverse events.
View Article and Find Full Text PDFDrugs
March 2025
Springer Nature, Mairangi Bay, Private Bag 65901, Auckland, 0754, New Zealand.
Revumenib (Revuforj) is an oral, first-in-class menin inhibitor developed by Syndax Pharmaceuticals for the treatment of KMT2A-rearranged (KMT2Ar) acute leukaemia, NPM1-mutated (NPM1m) acute myeloid leukaemia (AML) and solid tumours. The interaction between menin and the KMT2A protein complex leads to aberrant gene expression, driving leukaemogenic transcription. By blocking this interaction, revumenib promotes differentiation and exerts antileukaemic activity in KMT2Ar acute leukaemias and other menin inhibition-sensitive leukaemias.
View Article and Find Full Text PDFEnviron Monit Assess
March 2025
Faculty of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai, Johor Bahru, Johor, Malaysia.
In industrialized areas, air pollution is a recurring problem, especially in areas with high manufacturing and energy-intensive businesses. The challenge lies in the tension between industrial growth and environmental protection, as these sectors significantly contribute to pollution, resource depletion, and climate change. The objectives of the study were (1) to assess the contribution of each industrial group to the air quality in and around the Pasir Gudang industrial area, Malaysia, and (2) to evaluate the Air Pollution Index (API).
View Article and Find Full Text PDFAddict Sci Clin Pract
March 2025
The Substance Use Disorder Solutions Network, Wilmington, United States.
Background: Translating innovative research advancements into commercially viable medical interventions presents well-known challenges. However, there is limited understanding of how specific patient, clinical, social, and legal complexities have further complicated and delayed the development of new and effective interventions for Opioid Use Disorder (OUD). We present the following case studies to provide introductory clinical, social, and business insights for researchers, medical professionals, and entrepreneurs who are considering or are currently developing medical.
View Article and Find Full Text PDFMicrob Cell Fact
March 2025
Key Laboratory of Molecular Microbiology and Technology, College of Life Sciences, Ministry of Education, Nankai University, Tianjin, 300071, China.
Background: Hydrogen sulfide (HS) gas, characterized by its low odor threshold and toxicity, poses significant challenges in non-point source odor management. Traditional biotechnologies are effective in removing malodorous gases from point sources but they are limited for non-point source odor control.
Results: In this study, the sqr and pdo genes from Cupriavidus pinatubonensis JMP134 were introduced into the bacterial cellulose-producing strain Kosakonia oryzendophytica FY-07.
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