Spinal dissemination in epithelioid glioblastoma can be diagnosed by cerebrospinal fluid cytology and liquid biopsy to detect V600E mutation.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283864 | PMC |
http://dx.doi.org/10.1002/ccr3.4551 | DOI Listing |
Curr Oncol
November 2024
Pediatric Hematology/Oncology, Hospital Infantil Universitario "Niño Jesús", Universidad Autónoma de Madrid, 28009 Madrid, Spain.
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with a median overall survival (OS) of 15-18 months despite standard treatments. Approximately 8% of GBM cases exhibit genomic alterations in fibroblast growth factor receptors (FGFRs), particularly FGFR1 and FGFR3. Next-generation sequencing techniques have identified various FGFR3 fusions in GBM.
View Article and Find Full Text PDFAm J Cancer Res
October 2024
Department of Medicine, Chang Gung University Taoyuan 33305, Taiwan.
J Comp Pathol
November 2024
Institute of Infection, Veterinary and Ecological Sciences, Department of Veterinary Anatomy, Physiology and Pathology, University of Liverpool, Leahurst Campus, Neston, Wirral CH64 7TE, UK.
Astrocytomas are relatively common primary brain tumours of humans and companion animals. In dogs, they represent approximately 17-28% of primary central nervous system tumours. However, extracranial metastasis is extremely rare.
View Article and Find Full Text PDFSci Rep
October 2024
Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.
Glioblastomas (GBMs) are the most aggressive types of central nervous system tumors. Although certain genomic alterations have been identified as prognostic biomarkers of GBMs, the histomorphological features that predict their prognosis remain elusive. In this study, following an integrative diagnosis of 227 GBMs based on the 2021 World Health Organization classification system, the cases were histologically fractionated by cellular variations and abundance to evaluate the relationship between cellular heterogeneity and prognosis in combination with O-6-methylguanine-DNA methyltransferase gene promoter methylation (mMGMTp) status.
View Article and Find Full Text PDFNeurosurg Rev
October 2024
Medical Imaging Center, Guangdong Province, The First Affiliated Hospital of Jinan University, Tianhe District, No. 613, Huangpu Road West, Guangzhou, 510630, China.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!