Objective: To describe outcomes of critically ill patients with COVID-19, particularly the association of renal replacement therapy to mortality.
Design: A single-center prospective observational study was carried out.
Setting: ICU of a tertiary care center.
Patients: Consecutive adults with COVID-19 admitted to the ICU.
Intervention: Renal replacement therapy.
Main Variables Of Interest: Demographic data, medical history, illness severity, type of oxygen therapy, laboratory data and use of renal replacement therapy to generate a logistic regression model describing independent risk factors for mortality.
Results: Of the total of 166 patients, 51% were mechanically ventilated and 26% required renal replacement therapy. The overall hospital mortality rate was 36%, versus 56% for those requiring renal replacement therapy, and 68% for those with both mechanical ventilation and renal replacement therapy. The logistic regression model identified four independent risk factors for mortality: age (adjusted OR 2.8 [95% CI 1.8-4.4] for every 10-year increase), mechanical ventilation (4.2 [1.7-10.6]), need for continuous venovenous hemofiltration (2.3 [1.3-4.0]) and C-reactive protein (1.1 [1.0-1.2] for every 10mg/L increase).
Conclusions: In our cohort, acute kidney injury requiring renal replacement therapy was associated to a high mortality rate similar to that associated to the need for mechanical ventilation, while multiorgan failure necessitating both techniques implied an extremely high mortality risk.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294005 | PMC |
| http://dx.doi.org/10.1016/j.medine.2021.02.006 | DOI Listing |
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