How the cerebellum affects movement onset is poorly understood. In this issue of Neuron, Dacre et al. (2021) establish that in the context of operant conditioning, the transient activation of the cerebello-thalamo-cortical pathway to the motor cortex is sufficient to initiate the conditioned movement.
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Quantitative Oculomotor and Vestibular Profile in Spinocerebellar Ataxia Type 6 - Systematic Review and Meta-Analysis.
Cerebellum
December 2024
NeuroMetrology Lab, Nuffield Department of Clinical Neurosciences, Clinical Neurology, Medical Sciences Division, University of Oxford, Oxford, OX3 9DU, UK.
Whereas several studies have reported on quantitative oculomotor and vestibular measurements in spinocerebellar ataxia type 6 (SCA6), selecting the most suitable paradigms remains challenging. We aimed to address this knowledge gap through a systematic literature review and providing disease-specific recommendations for a tailored set of eye-movement recordings in SCA6. A literature search (MEDLINE, Embase) was performed focusing on studies reporting on quantitative oculomotor and/or vestibular measurements in SCA6-patients.
View Article and Find Full Text PDFExploration of (R)-[C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates.
Eur J Nucl Med Mol Imaging
December 2024
Center for Radiopharmaceutical Sciences, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, CH-8093, Switzerland.
Purpose: The monoacylglycerol lipase (MAGL) plays a pivotal role in modulating the endocannabinoid system and is considered an attractive therapeutic target for diseases in both the central nervous system and periphery. The current study aimed to develop and evaluate a suitable carbon-11 labeled tracer for imaging MAGL in preclinical studies.
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Center for Brain Disorders and Cognitive Sciences, School of Psychology, Shenzhen University, Shenzhen 518060, China; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China. Electronic address:
The preclinical stage of Alzheimer's Disease (AD) holds great potential for intervention, therefore, it is crucial to elucidate the neural mechanisms underlying the progression of subjective cognitive decline (SCD). Previous studies have predominantly focused on the neural changes in the cerebrum associated with SCD, but have relatively neglected the cerebellum, and its functional relationship with the cerebrum. In the current study, we employed dynamic functional connectivity and large-scale brain network approaches to investigate the pathological characteristics of dynamic brain states and cerebro-cerebellar collaboration between SCD (n = 32) and the healthy elderly (n = 29) using resting-state fMRI.
View Article and Find Full Text PDFNoise exposure-induced the cerebral alterations: From emerging evidence to antioxidant-mediated prevention and treatment.
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Research Center of Neuroscience, Jiaxing University, Jiaxing, China; Department of Physiology, Jiaxing University Medical College, Jiaxing, China. Electronic address:
It's well acknowledged that noise exposure has become a major environmental risk factor of public health. The previous standpoint holds that the main harm of noise exposure is to cause hearing loss of human. However, in the past two decades a large number of studies have linked the noise exposure to various cerebral changes.
View Article and Find Full Text PDFExtrauterine support of pre-term lambs achieves similar transcriptomic profiling to late pre-term lamb brains.
Sci Rep
November 2024
Department of Surgery, Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
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