Background: Numerous case-control studies have investigated the association between GSTP1 Ile105Val polymorphism and CHD risk, but the results from published studies were inconclusive. The present meta-analysis was performed to derive a more precise estimation.
Methods: PubMed, EMBASE, and Web of Science database searches were conducted to retrieve relevant articles.
Results: Ultimately, 5,451 CHD cases and 5,561 controls from 15 studies were included. Pooled analysis did not yield any statistically significant association between GSTP1 Ile105Val polymorphism and CHD risk for the overall population (Val vs. Ile: OR, 1.05; 95% CI, 0.93 to 1.18; Val/Val vs. Ile/Ile: OR, 1.09; 95% CI, 0.83 to 1.42; Val/Ile vs. Ile/Ile: OR, 1.09; 95% CI, 0.93 to 1.28; Val/Val vs. Val/Ile+Ile/Ile: OR, 1.04; 95% CI, 0.83 to 1.30; Val/Val+Val/Ile vs. Ile/Ile: OR, 1.14; 95% CI, 0.97 to 1.33). Subgroup analyses and sensitivity analyses indicated that GSTP1 Ile105Val polymorphism was still not associated with an increased risk of CHD. After excluding studies detected by Galbraith plots as major sources of heterogeneity, these relationships were still not significant.
Conclusions: The overall results did not reveal a major role of the GSTP1 Ile105Val polymorphism in modulating CHD risk. Well-designed studies with large sample sizes are needed to validate our findings and explore the possible gene-gene or gene-environment interactions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8297824 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254738 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Risk of Cardiovascular Complications Among Type 2 Diabetes Mellitus Patients with GSTP1 Genetic Polymorphism: A Nested Case-Control Study and Docking Studies.
Biochem Genet
May 2024
Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, 603103, India.
The genetic alteration in the antioxidant gene Glutathione-S-Transferases Pi 1 (GSTP1) namely GSTP1*IIe105Val (rs1695) and GSTP1*Ala114Val (rs1138272) changes the individual susceptibility to cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) by altering the substrate binding and catalytic activity. This study aims to investigate the association of GSTP1 rs1695 and rs1138272 polymorphism with CVD development in T2DM patients. Genotyping was performed with 400 study participants-group I: control; group II: T2DM; group III: CVD; and group IV: T2DM/CVD [n = 100 each] by PCR-RFLP.
View Article and Find Full Text PDFpolymorphism in the gene is associated with susceptibility to acute myeloid leukemia: an updated systematic review and meta-analysis.
Biomarkers
May 2024
Department of Medical Technology, College of Allied Medical Professions, Angeles University Foundation, Angeles City, Philippines.
Background And Objective: Several genetic variations are associated with acute myeloid leukemia (AML) susceptibility, including the polymorphism. Even with the existing meta-analysis conducted on the topic, no consensus has been reached since none of the studies available performed in-depth data analysis. Hence, we performed an updated systematic review and meta-analysis in this paper to obtain more precise estimates.
View Article and Find Full Text PDFGlutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study.
BMC Oral Health
February 2024
Clinic of Stomatology, Institution Shared with St. Anne's University Hospital, Faculty of Medicine, Masaryk University, Pekarska 664/53, Brno, 602 00, Czech Republic.
Background: Glutathione S-transferases (GSTs) play important roles in protecting cells against oxidative stress and toxic chemicals. This study aimed to investigate the distribution of GSTM1, GSTT1, and GSTP1 variants and their roles in periodontitis susceptibility in a Caucasian population.
Methods: We analyzed 406 participants, including 204 healthy controls and 203 periodontitis patients.
Factors associated with blood mercury concentrations and their interactions with three glutathione S-transferase genes (GSTT1, GSTM1, and GSTP1): an exposure assessment study of typically developing Jamaican children.
BMC Pediatr
January 2024
Department of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Article Synopsis
- - Jamaican children are exposed to mercury (Hg) primarily through their diet, particularly from consuming saltwater and canned fish, which can negatively affect neurodevelopment.
- - The study examined the relationship between environmental Hg exposure, specific GST genes (GSTT1, GSTM1, GSTP1), and blood mercury concentrations in a sample of 375 children aged 2-8.
- - Results showed that the impact of consuming canned fish on blood Hg levels is stronger in children with specific GSTP1 genotypes, emphasizing the need for further research in other populations.
Interactions between Environmental Factors and Glutathione S-Transferase (GST) Genes with Respect to Detectable Blood Aluminum Concentrations in Jamaican Children.
Genes (Basel)
October 2022
Louis A Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77054, USA.
Article Synopsis
- Aluminum can be toxic, especially from high dietary intake in children, and this study focused on 366 Jamaican children aged 2–8 to analyze factors contributing to detectable blood aluminum levels.
- The research found that eating string beans was linked to higher odds of detectable blood aluminum, while higher parental education was associated with lower odds.
- An interaction was noted between the consumption of saltwater fish and a specific GSTP1 genotype, indicating that children with a certain genetic makeup who ate saltwater fish showed significantly higher odds of having detectable blood aluminum levels.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!