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| http://dx.doi.org/10.1165/rcmb.2021-0209ED | DOI Listing |
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Key Laboratory of The Ministry of Education for Experimental Teratology, Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Liver cancer is the third leading cause of cancer-related deaths worldwide, with hepatocellular carcinoma (HCC) accounting for 85% of liver cancer-related deaths. Autophagy controls HCC cell growth, invasion, metastasis, drug resistance, and stemness. Spermatogenesis and oogenesis basic helix-loop-helix transcription factor 2 (Sohlh2) can bind to the E-boxes in the promoter regions of target genes, which are involved in multiple neoplasms.
View Article and Find Full Text PDFInhibition of transglutaminase 2 inhibits ionizing radiation-induced cellular senescence in skin keratinocytes in vitro.
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Laboratory of Intensive Care, Department of Intensive Care, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
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- Senescent cells are non-dividing cells associated with skin aging due to a specific secretory phenotype, but understanding skin aging has been limited by a lack of identified markers.
- Recent research indicates that intracellular calcium signaling is important in regulating cellular senescence, especially in skin keratinocytes, although its exact roles are still not fully understood.
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Effect of Ferulic Acid Loaded in Nanoparticle on Tissue Transglutaminase Expression Levels in Human Glioblastoma Cell Line.
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Department of Drug Sciences and Health, University of Catania, 95125 Catania, Italy.
Glioblastoma (GBM) is one of the most aggressive cancers, characterized by a decrease in antioxidant levels. Evidence has demonstrated that ferulic acid (FA), a natural antioxidant particularly abundant in vegetables and fruits, could be a promising candidate for GBM treatment. Since FA shows a high instability that compromises its therapeutic application, it has been encapsulated into Nanostructured Lipid Carriers (NLCs) to improve its bioavailability in the brain.
View Article and Find Full Text PDFIdentifying polyamine related biomarkers in diagnosis and treatment of ulcerative colitis by integrating bulk and single-cell sequencing data.
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Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ulcerative colitis (UC) is a chronic inflammatory disorder of the colon, and its pathogenesis remains unclear. Polyamine metabolic enzymes play a crucial role in UC. In this study, we aimed to identify pivotal polyamine-related genes (PRGs) and explore the underlying mechanism between PRGs and the disease status and therapeutic response of UC.
View Article and Find Full Text PDFA human autoimmune organoid model reveals IL-7 function in coeliac disease.
Nature
August 2024
Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
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- In vitro models studying autoimmunity often lack the complex immune environment and epithelial interactions necessary for accurate research, particularly regarding coeliac disease (CeD), which involves gluten triggering immune responses.
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