A new bioactive isocoumarin from the mangrove-derived fungus sp. TGM112.

J Asian Nat Prod Res

Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.

Published: July 2022

A new isocoumarin, penicimarin N (), along with five known compounds (), were isolated from the mangrove-derived fungus sp. TGM112. The structure of was elucidated on the basis of extensive spectroscopic data analysis, and the absolute configuration of was determined by comparison of their circular dichroism (CD) spectra with the literature. The structures of known compounds were determined by comparison with the literature data. All the isolated compounds were examined for their antioxidant and -glucosidase activities. Compound showed strong antioxidant activity with the IC value of 1.0 mM, and also exhibited moderate inhibitory activity against -glucosidase with the IC value of 620 μM.

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http://dx.doi.org/10.1080/10286020.2021.1952188DOI Listing

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