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Pharmacovigilance Pregnancy Data in a Population of Japanese Patients With Chronic Inflammatory Disease Exposed to Certolizumab Pegol.
Int J Rheum Dis
January 2025
Japan Drug Information Institute in Pregnancy, National Center for Child Health and Development, Tokyo, Japan.
Aim: Uncontrolled chronic inflammatory diseases (CIDs) before, during, and after pregnancy, as well as some CID medications, can increase the risk of impaired fertility in addition to adverse maternal/pregnancy outcomes in women of childbearing age. We report pregnancy outcomes from prospectively reported pregnancies in Japanese women treated with certolizumab pegol (CZP).
Methods: Data from July 2001 to November 2020 on CZP-exposed pregnancies from the CZP Pharmacovigilance safety database were reviewed.
Reaching 'outside the box': the value of cross specialty collaboration.
Eur J Cardiovasc Nurs
January 2025
KU Leuven Department of Public Health and Primary Care, KU Leuven, Kapucijnenvoer 7 PB7001, 3000 Leuven, Belgium.
DNA methylation patterns are influenced by Pax3::Foxo1 expression and developmental lineage in rhabdomyosarcoma tumours forming in genetically engineered mouse models.
J Pathol
January 2025
Laboratory of Pathology, Center for Cancer Research, NCI, Bethesda, MD, USA.
Rhabdomyosarcoma (RMS) is a family of phenotypically myogenic paediatric cancers consisting of two major subtypes: fusion-positive (FP) RMS, most commonly involving the PAX3::FOXO1 fusion gene, formed by the fusion of paired box 3 (PAX3) and forkhead box O1 (FOXO1) genes, and fusion-negative (FN) RMS, lacking these gene fusions. In humans, DNA methylation patterns distinguish these two subtypes as well as mutation-associated subsets within these subtypes. To investigate the biological factors responsible for these methylation differences, we profiled DNA methylation in RMS tumours derived from genetically engineered mouse models (GEMMs) in which various driver mutations were introduced into different myogenic lineages.
View Article and Find Full Text PDFObjective: To investigate young people's experience of retainer wear in the immediate term and at 6 months after appliance removal, and to explore the factors affecting retainer wear adherence.
Design: Qualitative study.
Setting: Orthodontic departments at two teaching hospitals in Yorkshire, UK.
Effectiveness of nurse-led progressive muscle relaxation on stress, anxiety, and depression in parents of adolescents with mental illness: A randomized controlled trial.
J Educ Health Promot
November 2024
Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India.
Background: Prevention of depression, stress, and anxiety is a serious concern of the World Health Organization and has been a research topic over the last decades. There is a close association found between children's mental health problems and parental stress, valid for biological and foster families. Evidence suggests that parents with children with disabilities are more stressed, depressed, or anxious than parents who do not have such children.
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