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| http://dx.doi.org/10.1128/JCM.01135-21 | DOI Listing |
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The metabolic and physiologic impairments underlying long COVID associated exercise intolerance.
Pulm Circ
October 2024
Department of Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine Yale School of Medicine New Haven Connecticut USA.
Data from invasive CPET (iCPET) revealed long COVID patients have impaired systemic oxygen extraction (EO), suggesting impaired mitochondrial ATP production. However, it remains uncertain whether the initial severity of SARS-CoV-2 infection has implications on EO and exercise capacity (VO) nor has there been assessment of anerobic ATP generation in long COVID patients. iCPET was performed on 47 long COVID patients (i.
View Article and Find Full Text PDFEpigenetic changes in patients with post-acute COVID-19 symptoms (PACS) and long-COVID: A systematic review.
Expert Rev Mol Med
October 2024
Centre for Environment and Health, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.
Background: Up to 30% of people infected with SARS-CoV-2 report disabling symptoms 2 years after the infection. Over 100 persistent symptoms have been associated with Post-Acute COVID-19 Symptoms (PACS) and/or long-COVID, showing a significant clinical heterogeneity. To develop effective, patient-targeted treatment, a better understanding of underlying mechanisms is needed.
View Article and Find Full Text PDFCCL2-mediated endothelial injury drives cardiac dysfunction in long COVID.
Nat Cardiovasc Res
October 2024
Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Article Synopsis
- The study showcases the connection between endothelial cells and cardiac injuries related to long COVID, particularly focusing on the cytokine CCL2.
- Researchers utilized patient tissues and induced stem cells to model conditions of endotheliitis, finding that CCL2 release leads to cardiac dysfunction after SARS-CoV-2 exposure.
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Osteoarticular mucormycosis of the distal femur in a post COVID-19 patient.
Med Mycol Case Rep
December 2024
Orthopaedics, Krishna Institute of Medical Sciences, Secunderabad, Telangana, India.
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Meningococcal Pneumonia in a Patient With Pulmonary Amyloidosis and a Recent COVID-19 Infection.
Cureus
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Respiratory Medicine, Japanese Red Cross Society Kyoto Daiichi Hospital, Kyoto, JPN.
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- A 64-year-old man with a history of pulmonary amyloidosis and recent COVID-19 presented with high fever and throat pain, indicating potential bronchopneumonia.
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