AI Article Synopsis
- - Behçet's disease (BD) is a serious condition that causes long-lasting damage, and there's a need for better tools to assess this damage efficiently.
- - A study involving 1,252 BD patients aimed to create and validate a simple BD Damage Index (BDI) through three stages: generating items for the score, selecting relevant items with expert input, and testing its validity against other established indices.
- - The final BDI tool includes 73 items and showed a strong correlation with other damage assessment scores, indicating it could be a valuable resource for evaluating the chronic status of BD.
Article Abstract
Background: Behçet's disease (BD) is a chronic multisystem variable vessel vasculitis. Disease damage is irreversible and permanent. Validated tools evaluating damage are limited. Enhancements in the clinical treatment of vasculitis will take place from the development of refined and exclusive indices for individual vasculitic syndromes including BD and attempting their international validation.
Objectives: This aim was to develop and validate a simple BD Damage Index (BDI).
Methods: This was a nationwide study including 1252 BD patients. The work consisted of 3 stages. Stage 1: items generation for score content. Stage 2: items selection for the draft score was performed by an expert rheumatologist. Stage 3: the content validity of the draft score was assessed and BDI, Vasculitis Damage Index (VDI), Antineutrophil cytoplasmic antibody-associated Vasculitis Index of Damage (AVID) and Combined Damage Assessment Index (CDAI) were calculated and compared.
Results: The mean age of the BD patients was 36.1 ± 9.9 years. Stages 1 and 2 resulted in a BDI instrument containing 73 items with a maximum score of 100. Stage 3, the VDI, CDAI, AVID, and BDI were 2.9 ± 2.2, 3.1 ± 2.3, 3.1 ± 2.3 and 5.1 ± 2.9, respectively. High correlations (r = .9) between comparable damage scores assured acceptable concurrent validity.
Conclusion: The proposed BDI represents a new robust and potentially useful tool when dealing with BD chronic status.
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| http://dx.doi.org/10.1111/1756-185X.14166 | DOI Listing |
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