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Tudor staphylococcal nuclease is a docking platform for stress granule components and is essential for SnRK1 activation in Arabidopsis. | LitMetric

AI Article Synopsis

  • Tudor staphylococcal nuclease (TSN) is a multifunctional protein involved in gene regulation and stress response, showing different roles in plants and mammals.
  • In the plant Arabidopsis thaliana, TSN acts as a scaffold for other proteins associated with stress granules, with a majority of its interactors already present before stress occurs.
  • The study reveals that TSN aids in stress granule formation, which is linked to the activation of a key energy-sensing kinase, SnRK1, crucial for the plant's response to stress.

Article Abstract

Tudor staphylococcal nuclease (TSN; also known as Tudor-SN, p100, or SND1) is a multifunctional, evolutionarily conserved regulator of gene expression, exhibiting cytoprotective activity in animals and plants and oncogenic activity in mammals. During stress, TSN stably associates with stress granules (SGs), in a poorly understood process. Here, we show that in the model plant Arabidopsis thaliana, TSN is an intrinsically disordered protein (IDP) acting as a scaffold for a large pool of other IDPs, enriched for conserved stress granule components as well as novel or plant-specific SG-localized proteins. While approximately 30% of TSN interactors are recruited to stress granules de novo upon stress perception, 70% form a protein-protein interaction network present before the onset of stress. Finally, we demonstrate that TSN and stress granule formation promote heat-induced activation of the evolutionarily conserved energy-sensing SNF1-related protein kinase 1 (SnRK1), the plant orthologue of mammalian AMP-activated protein kinase (AMPK). Our results establish TSN as a docking platform for stress granule proteins, with an important role in stress signalling.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447601PMC
http://dx.doi.org/10.15252/embj.2020105043DOI Listing

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