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Exposed Phosphatidylserine as a Biomarker for Clear Identification of Breast Cancer Brain Metastases in Mouse Models.
Cancers (Basel)
September 2024
Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Brain metastasis is the most common intracranial malignancy in adults. The prognosis is extremely poor, partly because most patients have more than one brain lesion, and the currently available therapies are nonspecific or inaccessible to those occult metastases due to an impermeable blood-tumor barrier (BTB). Phosphatidylserine (PS) is externalized on the surface of viable endothelial cells (ECs) in tumor blood vessels.
View Article and Find Full Text PDFBioactive compound from marine seagrass Streptomyces argenteolus TMA13: combatting fish pathogens with time-kill kinetics and live-dead cell imaging.
Braz J Microbiol
September 2024
Actinobacterial Research Laboratory, Department of Microbiology, Periyar University, Salem, 636011, Tamil Nadu, India.
Actinobacteria, pervasive in aquatic and terrestrial environments, exhibit a filamentous morphology, possess DNA with a specific G + C content and production of numerous secondary metabolites. This study, focused on actinobacteria isolated from marine seagrass, investigating their antibacterial activity against fish pathogens. Among 28 isolates, Streptomyces argenteolus TMA13 displayed the maximum zone of inhibition against fish pathogens-Aeromonas hydrophila (10 mm), Aeromonas caviae (22 mm), Edwardsiella tarda (17 mm), Vibrio harveyi (22 mm) and Vibrio anguillarum (12 mm) using the agar plug method.
View Article and Find Full Text PDFInhibition of endocytic uptake of severe acute respiratory syndrome coronavirus 2 and endo-lysosomal acidification by diphenoxylate.
Antimicrob Agents Chemother
June 2024
Infectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon, Republic of Korea.
Article Synopsis
- - Cell culture screening identified diphenoxylate as a potential antiviral drug against SARS-CoV-2, with effective concentrations between 1.4 and 4.9 µM for various virus strains.
- - Diphenoxylate functions as an entry blocker that prevents the virus from penetrating cells and disrupts endo-lysosomal acidification, demonstrating enhanced effects when used with the TMPRSS2 inhibitor nafamostat.
- - In a transgenic mouse model, intranasal diphenoxylate administration reduced viral RNA in lungs by 70%, suggesting it could lead to effective antiviral therapies through further chemical modifications.
Label-free visualization and quantification of the drug-type-dependent response of tumor spheroids by dynamic optical coherence tomography.
Sci Rep
February 2024
Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, 305-8573, Japan.
We demonstrate label-free dynamic optical coherence tomography (D-OCT)-based visualization and quantitative assessment of patterns of tumor spheroid response to three anti-cancer drugs. The study involved treating human breast adenocarcinoma (MCF-7 cell-line) with paclitaxel (PTX), tamoxifen citrate (TAM), and doxorubicin (DOX) at concentrations of 0 (control), 0.1, 1, and 10 µM for 1, 3, and 6 days.
View Article and Find Full Text PDFThe relationship between surface drug distribution of Dox-loaded microbubbles and drug release/cavitation behaviors with ultrasound.
Ultrason Sonochem
January 2024
Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan. Electronic address:
Ultrasound (US)-triggered microbubbles (MBs) drug delivery is a promising tool for noninvasive and localized therapy. Several studies have shown the potential of drug-loaded MBs to boost the delivery of therapeutic substances to target tissue effectively. Nevertheless, little is known about the surface payload distribution affecting the cavitation activity and drug release behavior of the drug-loaded MBs.
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