Aurora A kinase activation: Different means to different ends.

J Cell Biol

Programme équipe Labellisée Ligue Contre le Cancer - Université de Paris, Centre National de la Recherche Scientifique, Institut Jacques Monod, Paris, France.

Published: September 2021

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Article Abstract

Aurora A is a serine/threonine kinase essential for mitotic entry and spindle assembly. Recent molecular studies have revealed the existence of multiple, distinct mechanisms of Aurora A activation, each occurring at specific subcellular locations, optimized for cellular context, and primed by signaling events including phosphorylation and oxidation.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298103PMC
http://dx.doi.org/10.1083/jcb.202106128DOI Listing

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