A Wolf in Sheep's Clothing: Collision of Melanoma and Keratoacanthoma.

Dermatopathology (Basel)

Skinpath-Histopathology, 5600 Lenzburg, Switzerland.

Published: July 2021

AI Article Synopsis

  • Collision tumors like melanoma and squamous cell carcinoma are uncommon, and this case illustrates a unique occurrence.
  • A 72-year-old woman's forearm nodule appeared to be a squamous cell carcinoma but was actually coexisting with an epithelioid melanoma upon histological examination.
  • The report emphasizes the need for prompt histopathological and immunohistochemical analysis to avoid delays in diagnosis and treatment that could worsen patient outcomes.

Article Abstract

Collision tumors consisting of melanoma and squamous cell carcinoma are very rare. We present the case of a deceptive hyperkeratotic nodule on the forearm of a 72-year-old woman, which clinically appeared to be a squamous cell carcinoma, keratoacanthoma type. Histological examination surprisingly revealed a coexisting epithelioid melanoma. Thus, this case report shows the importance of an early histopathological and immunohistochemical workup to prevent unnecessary diagnostic and therapeutic delay with negative effects on prognosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293117PMC
http://dx.doi.org/10.3390/dermatopathology8030030DOI Listing

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