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Impact of primary sequence changes on the self-association properties of mammalian cystathionine beta-synthase enzymes.
Protein Sci
December 2024
Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Cystathionine beta-synthase (CBS) is an evolutionarily conserved enzyme that plays a key role in mammalian sulfur amino acid biochemistry, mutations in which are the cause of classical homocystinuria (HCU), an inborn error of metabolism. Although there is agreement in the literature that CBS is a homomultimer, its precise structure is a source of confusion. Here, we performed a series of experiments examining the quaternary structure of various wild-type and mutant CBS enzymes using a combination of native gel electrophoresis, in situ activity assays, analytical ultracentrifugation, and gel filtration.
View Article and Find Full Text PDFLessons from the Department of Veterans Affairs: A continuum of age-friendly care for older adults.
J Am Geriatr Soc
October 2024
Department of Veterans Affairs, Veterans Health Administration, Office of Geriatrics and Extended Care, Washington, DC, USA.
With almost 90% of Americans expressing a desire to age in place in their home, many health systems and communities are challenged to provide the right resources, at the right time, to support What Matters to older adults. In the Department of Veterans Affairs (VA), approximately 50% of Veterans enrolled in VA health care are aged 65 and older, driving an imperative to provide timely, Age-Friendly care through a broad continuum of services. VA has taken a multifaceted approach to shift Long-Term Services and Supports to promote aging in place through innovation pilots, expansion of Home and Community Based Services (HCBS) and adoption of Age-Friendly Health Systems (AFHS) practices [or "framework"].
View Article and Find Full Text PDFInequities in medicaid home- and community-based services waiver enrollment among people with intellectual and/or developmental disabilities: A nationwide claims-based analysis.
Disabil Health J
August 2024
Department of Epidemiology, Boston University School of Public Health, 715 Albany St, Talbot Building T3E, Boston, MA, 02118, USA.
Background: States use Medicaid 1915(c) waiver programs to enable access to home- and community-based services for people with intellectual and/or developmental disabilities (I/DD). However, enrollment rates and potential inequities are not well documented, impeding efforts to improve care access and quality for waiver program enrollees, especially for racially minoritized beneficiaries experiencing compounded barriers to services and supports.
Objective: To characterize year-by-year 1915(c) waiver program enrollment among Medicaid-enrolled adults with I/DD from 2016 to 2019 and to analyze population-level inequities by type of I/DD and racial/ethnic group.
MRl and MRS hints for the differentiation of cerebellar multiple system atrophy from spinocerebellar ataxia type II.
Heliyon
April 2024
Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan.
Background And Objectives: The differentiation of spinocerebellar ataxia type II (SCA 2) from idiopathic multiple systemic atrophy of the cerebellar type (MSA-C) is often difficult in patients with cerebellar ataxia when molecular testing is not available. Besides genetic testing, magnetic resonance imagining (MRI) and magnetic resonance spectroscopy (MRS) prove to be beneficial. Nevertheless, the characteristics observed through radiology change as the disease advances.
View Article and Find Full Text PDFDifferences in healthcare utilization between enrollees of fully integrated dual eligible special needs plans versus non-fully integrated plans.
J Am Geriatr Soc
July 2024
Division of General Internal Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Article Synopsis
- Policymakers are pushing for care integration models, like fully integrated dual eligible (FIDE) plans, to improve service coordination for individuals eligible for both Medicare and Medicaid.
- A study analyzed healthcare utilization between FIDE and non-FIDE plan enrollees aged 65 and older, adjusting for various factors using data from six states in 2018.
- Overall, there were no significant differences in healthcare usage between the two plan types, but specific subgroups, like home and community-based service users, showed benefits in the FIDE plans, such as fewer hospitalizations and higher rates of discharge to home.
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