AI Article Synopsis
- - The study evaluates the psychometric performance of the NCCN-FACT Ovarian Cancer Symptom Index-18 (NFOSI-18) in patients with advanced ovarian cancer, using observational data from 897 patients undergoing treatment.
- - It assesses factors like internal consistency reliability and construct validity, finding that the NFOSI-18 scores show acceptable reliability and correlate well with other established quality of life measures.
- - The results indicate specific clinically important differences associated with various symptoms and treatment effects, which can help in interpreting treatment outcomes in clinical trials.
Article Abstract
To evaluate psychometric performance of the NCCN-FACT Ovarian Cancer Symptom Index-18 (NFOSI-18) in advanced ovarian cancer. Cross-sectional, observational data from patients receiving treatment for ovarian cancer. Other measures included European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core (EORTC QLQ-C30) and associated ovarian cancer module (EORTC QLQ-OV28) and Work Productivity and Activity Impairment. Internal consistency reliability, construct validity and anchor-based clinically important differences were assessed. 897 patients were analyzed. Reliability was acceptable for all NFOSI-18 scores; construct validity was supported. Twelve anchors sufficiently correlated with NFOSI-18 scores and suggested clinically important differences: NFOSI-18 total score (5-7), disease-related symptoms - physical (3-4), disease-related symptoms - emotional (1), treatment side effects (2) and functional well-being (1-2). Results provide evidence of reliability and validity of NFOSI-18 scores. Generated CIDs will help improve interpretation of between-group treatment differences in clinical trials.
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| http://dx.doi.org/10.2217/fon-2021-0358 | DOI Listing |
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