Chemokines with their network play an important role in cancer growth, metastasis, and host-tumor interactions. Of many chemokines, C-C motif chemokine ligand 24 (CCL24) has been shown to contribute to tumorigenesis as well as inflammatory diseases like asthma, allergies, and eosinophilic esophagitis. CCL24 is expressed in some tumor cells such as colon cancer, hepatocellular carcinoma, and cutaneous T cell lymphoma. CCL24 can be used as a potential biomarker in several cancers including colon cancer, non-small cell cancer, and nasopharyngeal carcinoma as the plasma level of CCL24 is increased. The various functions of CCL24 contribute to the biology of cancer by M2 macrophage polarization, angiogenesis, invasion and migration, and recruitment of eosinophils.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/978-3-030-62658-7_7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identification and Validation of Epithelial Cell Centre Regulatory Transcription Factors in the Gastric Cancer Microenvironment.
Int J Gen Med
December 2024
Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yun Nan, People's Republic of China.
Purpose: To identify the epithelial cell centre regulatory transcription factors in the gastric cancer (GC) microenvironment and provide a new strategy for the diagnosis and treatment of GC.
Methods: The GC single-cell dataset was downloaded from the Gene Expression Omnibus (GEO) database. The regulatory mechanisms of transcription factors in both pan-cancer and GC microenvironments were analysed using the Cancer Genome Atlas (TGCA) database.
Risk signature of NETosis-related subtype predicts prognosis and evaluates immunotherapy effectiveness in gastric cancer.
Transl Cancer Res
October 2024
Medical College, Qingdao University, Qingdao, China.
Background: Gastric cancer (GC) has a high incidence and mortality rate with a poor prognosis, so it is crucial to search for new biomarkers. The role of NETosis, a newly identified type of programmed cell death, in GC and its underlying mechanisms have yet to be explored and still require thorough investigation. Our research seeks to enhance our comprehension of NETosis and may offer novel approaches for treating GC.
View Article and Find Full Text PDFVariance quantitative trait loci reveal gene-gene interactions which alter blood traits.
medRxiv
September 2024
Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA.
Article Synopsis
- Gene-gene interactions (GxG) are crucial for understanding the genetic basis of traits and diseases, helping to explain the "missing heritability" in both polygenic and monogenic traits in humans.* -
- Researchers employed two variance QTL (vQTL) methods to uncover GxG interactions linked to human blood traits and disease risk, using data from large cohorts like the UK Biobank, NIH All of Us, and Vanderbilt BioVU.* -
- The study revealed significant GxG interactions, including known and novel ones affecting eosinophil and lymphocyte counts, as well as the risk of celiac disease and hematological conditions, showcasing the effectiveness of vQTL approaches in human health research.*
Using inflammatory biomarkers in early pregnancy to predict subsequent antenatal depression.
J Affect Disord
February 2025
Experiment Center, Capital Institute of Pediatrics, Beijing, China. Electronic address:
Background: Antenatal depression (AD) is one of the most common pregnancy complications. Recent studies indicated that immune responses during pregnancy may contribute to development of AD.
Objectives: This study aimed to identify possible inflammatory biomarkers in early pregnancy to predict maternal depressive symptoms before delivery.
A subpopulation of human bone marrow erythroid cells displays a myeloid gene expression signature similar to that of classic monocytes.
PLoS One
July 2024
Laboratory of Molecular Immunology, Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
Erythroid cells, serving as progenitors and precursors to erythrocytes responsible for oxygen transport, were shown to exhibit an immunosuppressive and immunoregulatory phenotype. Previous investigations from our research group have revealed an antimicrobial gene expression profile within murine bone marrow erythroid cells which suggested a role for erythroid cells in innate immunity. In the present study, we focused on elucidating the characteristics of human bone marrow erythroid cells through comprehensive analyses, including NanoString gene expression profiling utilizing the Immune Response V2 panel, a BioPlex examination of chemokine and TGF-beta family proteins secretion, and analysis of publicly available single-cell RNA-seq data.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!