AI Article Synopsis
- - The World Health Organization recommends corticosteroids for severe COVID-19, and studies show dexamethasone can lower mortality rates in these patients.
- - A case study highlights the progression of a mildly symptomatic COVID-19 patient to critical illness, showcasing significant recovery with corticosteroids during early deterioration.
- - The article discusses the optimal timing and dosage for corticosteroid use in COVID-19 pneumonia treatment, linking it to the underlying cytokine storm and viral load issues.
Article Abstract
Background: The World Health Organization (WHO) strongly suggests using corticosteroids in patients with severe coronavirus disease 2019 (COVID-19). Similarly, a large randomized controlled clinical trial (RCT) in the UK found that dexamethasone effectively reduced the mortality rate in severe COVID-19 patients. However, the safety profile of corticosteroids has been a controversial area of study.
Case Description: A case of a COVID-19 patient is described and the clinical characteristics are observed as the mildly symptomatic patient progresses into a critically ill patient and during their dramatic improvement with corticosteroid therapy in the early stage of the deterioration process with COVID-19 pneumonia.
Conclusion: The most suitable timing and dosage for the use of corticosteroids to maximize its effect during the worsening of COVID-19 pneumonia are discussed. One of the main pathophysiological hypotheses for severe COVID-19 patients is related to cytokine storm and virus load, which can be effectively treated with corticosteroid therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285565 | PMC |
| http://dx.doi.org/10.2147/IDR.S314938 | DOI Listing |
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