Objective: This study was performed to compare the genetic diversity, virulence, and antimicrobial resistance of strains isolated from patients and healthy individuals.
Methods: A total of 38 clinical strains and 19 strains from healthy individuals were isolated from the samples collected in Ma'anshan City, Anhui Province. Their taxonomy was investigated using concatenated - sequences, and their resistance to 12 antibiotics was evaluated. The pathogenicity of these strains was examined through beta-hemolysis, protease activity, and virulence gene assays.
Results: The 57 strains were divided into 55 sequence types. Of these types, 21 were novel, suggesting that their genetic diversity was high. These isolates could be divided into 7 species, and the positive rates of beta-hemolysis and protease activity were 49.1% and 73.7%, respectively. The detection rate of clinical patients in terms of beta-hemolysis and protease activity was higher than that of healthy individuals. Among the four most common strains, had the highest detection rate of virulence genes. The multidrug resistance rate of the clinical isolates was much higher than that of the strains isolated from healthy individuals.
Conclusions: The taxonomy, virulence properties, and antibiotic resistance of isolates from patients differ from those of the isolates from healthy individuals.
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