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| http://dx.doi.org/10.1038/s41380-021-01221-y | DOI Listing |
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Unlocking the catalytic precision of ligand-controlled enzymatic halogenation.
Proc Natl Acad Sci U S A
January 2025
School of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Rayong 10120, Thailand.
A single-component flavin-dependent halogenase, AetF, has emerged as an attractive biocatalyst for catalyzing halogenation. However, its flavin chemistry remains unexplored and cannot be predicted due to its uniqueness in sequence and structure compared to other flavin-dependent monooxygenases. Here, we investigated the flavin reactions of AetF using transient kinetics.
View Article and Find Full Text PDFUnlocking the therapeutic potential and personalized therapy of testosterone: a comprehensive review.
Drug Metab Pers Ther
November 2024
Department of Pharmacology, 29988 Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Article Synopsis
- Testosterone is a key male hormone involved in sex differentiation and development, primarily produced in the testes and related glands from cholesterol.
- The review highlights various studies exploring testosterone's potential benefits beyond its current use for treating specific hormonal disorders, specifically looking at its effects on conditions like anxiety and diabetes.
- The authors aim to promote an understanding of testosterone's therapeutic uses while advocating for optimal hormonal balance to improve health outcomes for conditions such as obesity and depression.
The β-subunit of tryptophan synthase is a latent tyrosine synthase.
Nat Chem Biol
August 2024
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.
Aromatic amino acids and their derivatives are diverse primary and secondary metabolites with critical roles in protein synthesis, cell structure and integrity, defense and signaling. All de novo aromatic amino acid production relies on a set of ancient and highly conserved chemistries. Here we introduce a new enzymatic transformation for L-tyrosine synthesis by demonstrating that the β-subunit of tryptophan synthase-which natively couples indole and L-serine to form L-tryptophan-can act as a latent 'tyrosine synthase'.
View Article and Find Full Text PDFA modular and synthetic biosynthesis platform for de novo production of diverse halogenated tryptophan-derived molecules.
Nat Commun
April 2024
McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX, USA.
Halogen-containing molecules are ubiquitous in modern society and present unique chemical possibilities. As a whole, de novo fermentation and synthetic pathway construction for these molecules remain relatively underexplored and could unlock molecules with exciting new applications in industries ranging from textiles to agrochemicals to pharmaceuticals. Here, we report a mix-and-match co-culture platform to de novo generate a large array of halogenated tryptophan derivatives in Escherichia coli from glucose.
View Article and Find Full Text PDFPhytomedicine Fructus Aurantii-derived two absorbed compounds unlock antidepressant and prokinetic multi-functions via modulating 5-HT/GHSR.
J Ethnopharmacol
April 2024
Institute of TCM-Related Comorbid Depression, Nanjing University of Chinese Medicine, Nanjing 210023, China; Medical College, Xiamen University, School of Medicine, Xiamen, 361102, China. Electronic address:
Ethnopharmacological Relevance: Fructus Aurantii (FA), a well-known phytomedicine, has been employed to evoke antidepressant and prokinetic multi-functions. Therein, systematically identifying bioactive components and the referred mechanism is essential for FA.
Aim Of The Study: This study was planned to answer "2 W" (What and Why), such as which components and pathways contribute to FA's multi-functions.
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