Geometrical symmetry plays a significant role in implementing robust, symmetry-protected, bound states in the continuum (BICs). However, this benefit is only theoretical in many cases since fabricated samples' unavoidable imperfections may easily break the stringent geometrical requirements. Here we propose an approach by introducing the concept of geometrical-symmetry-free but symmetry-protected BICs, realized using the static-like environment induced by a zero-index metamaterial (ZIM). We find that robust BICs exist and are protected from the disordered distribution of multiple objects inside the ZIM host by its physical symmetries rather than geometrical ones. The geometric-symmetry-free BICs are robust, regardless of the objects' external shapes and material parameters in the ZIM host. We further show theoretically and numerically that the existence of those higher-order BICs depends only on the number of objects. By practically designing a structural ZIM waveguide, the existence of BICs is numerically confirmed, as well as their independence on the presence of geometrical symmetry. Our findings provide a way of realizing higher-order BICs and link their properties to the disorder of photonic systems.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290025 | PMC |
http://dx.doi.org/10.1038/s41467-021-24686-5 | DOI Listing |
Hepatology
March 2025
Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China.
Background And Aims: Portal vein tumor thrombosis (PVTT), an indicator of clinical metastasis, significantly shortens hepatocellular carcinoma (HCC) patients' lifespan, and no effective treatment has been established. We aimed to illustrate mechanisms underlying PVTT formation and tumor metastasis, and identified potential targets for clinical intervention.
Approach And Results: Multi-omics data of 159 HCC patients (including 37 cases with PVTT) was analyzed to identify contributors to PVTT formation and tumor metastasis.
J Immunol
February 2025
HIV Immunopathogenesis Laboratory, BEAT-HIV Delaney Collaboratory, Wistar Institute, Philadelphia, PA, United States.
Natural killer (NK) cells can efficiently mediate antibody-dependent cellular cytotoxicity (ADCC) of antibody coated target cells via the low-affinity Fc-receptor, CD16, but cannot retain antibodies over time. To increase antibody retention and facilitate targeted ADCC, we genetically modified human NK cells with the high-affinity Fc receptor, CD64, so that we could preload them with HIV-specific broadly neutralizing antibodies (BNAbs) and enhance their capacity to target HIV-infected cells via ADCC. Purified NK cells from the peripheral blood of control donors or persons living with HIV were activated with interleukin (IL)-2/IL-15/IL-21 cytokines and transduced with a lentivirus encoding CD64.
View Article and Find Full Text PDFJ Immunol
March 2025
Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, United States.
B cell depletion is an efficacious therapy for multiple sclerosis, but its long-term safety profile in the gastrointestinal tract has not been specifically studied. This is of importance because the gut is the largest reservoir of IgA in the body, which maintains gut homeostasis in part by regulating the composition of the gut microbiota. This was addressed by development of a prolonged B cell depletion model using human CD20 transgenic mice and B cell depletion with the anti-human CD20 antibodies rituximab, a humanized mouse monoclonal, and 2H7, the mouse precursor to ocrelizumab.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
March 2025
Department of Hepatobiliary and Pancreatic Surgery and Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Chronic infections with hepatitis E virus (HEV), especially those of genotype 3 (G3), frequently lead to liver fibrosis and cirrhosis in patients. However, the causation and mechanism of liver fibrosis triggered by chronic HEV infection remain poorly understood. Here, we found that the viral multiple-domain replicase (ORF1) undergoes unique ubiquitin-proteasomal processing leading to formation of the EV-erived MAD ctivator (HDSA), a viral polypeptide lacking putative helicase and RNA polymerase domains.
View Article and Find Full Text PDFThis article deals with the observer-based control problem of networked periodic piecewise systems under encoding-decoding frameworks. An encoder with a uniform quantizer, which can compress and encrypt data, is provided to process the measurements from the sensors. The processed data is transmitted over the network to the decoder to recover the original data and then to the remote control station, thereby reducing the communication burden and ensuring data security.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!