Thousands of drugs and nutraceuticals along with their combinations can be used to select candidate therapeutics for targeting the transmission, proliferation and the fatal or severe symptoms of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in order to reduce the unacceptably high mortality rate observed in the coronavirus disease 2019 (COVID-19) pandemic and its associated negative effects on daily life worldwide [...].
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http://dx.doi.org/10.3390/ijms22137208 | DOI Listing |
Parasit Vectors
December 2024
Global Health and Tropical Medicine- Institute of Hygiene and Tropical Medicine, NOVA University of Lisbon, Rua da Junqueira 100, 1349-008, Lisbon, Portugal.
Background: Tick-borne rickettsioses (TBR) are emerging, neglected, zoonoses, caused by intracellular α-proteobacteria of the genus Rickettsia, that pose a growing public health concern. The aim of the present study was to evaluate rickettsial infections in questing ticks collected from four different ecological areas in mainland Portugal.
Methods: Over a two-year period, a total of 707 questing ticks were collected.
Sci Total Environ
December 2024
State Key Joint Laboratory of Environmental Simulation & Pollution Control, School of Environment, Beijing Normal University, Beijing 100875, China; Center for Atmospheric Environmental Studies, Beijing Normal University, Beijing 100875, China.
Iron and steel production (ISP) is one of significant atmospheric pollution emission sources in China. With the implementation of ultra-low emission (ULE) standards, a detailed and new updated emission inventory is urgently needed for better understanding of the temporal trends and spatial variation of emission characteristics. In this study, a unit-based comprehensive emission inventory of multiple hazardous air pollutants (HAPs) for the Chinese ISP spanned from 2012 to 2021, including the conventional pollutants, 13 kinds of Trace elements as well as 2 unconventional but toxic pollutants (PCDD/Fs, F), was dedicatedly developed by integrating dynamic localized emission factors with unit-based information of both the detailed activity level and abatement technology application.
View Article and Find Full Text PDFCell Rep
December 2024
Rudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, 04103 Leipzig, Germany. Electronic address:
Adhesion G protein-coupled receptors (aGPCRs) are expressed in all organs and are involved in various mechanobiological processes. They are heavily alternatively spliced, forecasting an extraordinary molecular structural diversity. Here, we uncovered the existence of unconventional single-transmembrane (1TM)-containing ADGRL/Cirl proteins devoid of the conventional GPCR layout (i.
View Article and Find Full Text PDFTrop Anim Health Prod
December 2024
Animal Husbandry Department, Kishtwar, Jammu, 182204, Jammu and Kashmir, India.
The global goat population continues to grow, and simultaneously, fodder demand is increasing, despite the fact that feed resources are limited, and thus, new unconventional feed resources should be explored. The present study focuses on the nutrient utilization of ten top feeds viz. Acacia nilotica, Celtis australis, Ficus palmata, Ficus religiosa, Grewia optiva, Melia azadarach, Morus alba, Quercus incana, Salix alba and Zizyphus jujuba.
View Article and Find Full Text PDFCase Rep Crit Care
December 2024
Department of Emergency Medicine, University of California San Francisco, San Francisco, California, USA.
Coingestion of cardiovascular drugs with angiotensin-converting enzyme inhibitors (ACEIs) can be associated with refractory shock derangements complicated by vasopressor resistance, prompting the use of novel, unconventional, or uncommonly used agents. A young adult male presented to the emergency department (ED) 10 h after ingesting lisinopril and amlodipine. On arrival, he was hypotensive with a blood pressure of 72/39 mmHg.
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