Objective: To examine the changes in AMH levels longitudinally over time and their relationship with both body composition, particularly abdominal adiposity, and milestones of pubertal development in female children.
Design: Secondary analysis of a prospective, longitudinal study.
Setting: University affiliated research center and laboratories.
Patients: Eighty-nine females were examined between 1990 and 2015 to study child growth and development.
Interventions: Demographic, anthropometric, growth, and pubertal milestone data with serum samples stored and subsequently analyzed for AMH.
Main Outcome Measures: Longitudinal change in AMH and predicted AMH levels based on body composition, age, and pubertal milestones including, pubarche, thelarche, and menarche.
Results: Natural log-transformed AMH (AMH) levels appeared to have a nonlinear relationship with age, decreasing between 10 and 14 years of age, increasing until 16 years. A mixed effect linear model demonstrated that increased abdominal adiposity (waist/height ratio, WHtR) was significantly associated with the predicted increased AMH levels (β=1.37). As females progressed through the Tanner stages, the model predicted decreasing AMH values when adjusting for age and WHtR.
Conclusions: Declining AMH levels during puberty may not be reflective of diminished ovarian reserve as observed in adults, but may suggest a permissive role of AMH in the activation of the hypothalamic-pituitary-ovarian axis.
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| http://dx.doi.org/10.1016/j.xfre.2021.02.001 | DOI Listing |
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