AI Article Synopsis
- Genetic screens help pinpoint genes tied to biological processes, with a focus on growth control in developing eyes through EMS mutagenesis.
- One mutant line was examined using the FLP/FRT system and analyzed for genetic mapping through student-led efforts in the Fly-CURE consortium.
- The study revealed a nonsense mutation in a gene linked to spectraplakin, which is important for cytoskeletal organization and influences cell growth and proliferation.
Article Abstract
Genetic screens are used to identify genes involved in specific biological processes. An EMS mutagenesis screen in identified growth control phenotypes in the developing eye. One mutant line from this screen, , was phenotypically characterized using the FLP/FRT system and genetically mapped by complementation analysis and genomic sequencing by undergraduate students participating in the multi-institution Fly-CURE consortium. was found to have a nonsense mutation in (), anortholog of the mammalian spectraplakin (). and are involved in cytoskeletal organization and play roles during cell growth and proliferation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278230 | PMC |
| http://dx.doi.org/10.17912/micropub.biology.000418 | DOI Listing |
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