had been used for numerous medical and cosmetic applications since ancient times. The study aimed to investigate the integrated effects of inorganic fertilizer (IF) and poultry manure (PM) on the nutritional and pharmaceutical constituents of . Eighteen month old seedlings were used following completely randomized design with three replications. Six combinations of IF [Nitrogen (N), phosphorus (P), potassium (K) and sulphur (S) at the rate of 150, 80, 120 and 30 kg ha, respectively] and PM (at the rate of 5 t ha) were considered ., IFPM (IF = 0%, PM = 0%), IFPM(IF = 100%, PM = 0%), IFPM (IF = 75%, PM = 25%), IFPM (IF = 50%, PM = 50%), IFPM (IF = 25%, PM = 75%) and IFPM (IF = 0%, PM = 100%) as treatments. Different treatment combinations of IF and PM exerted significant influence on the nutritional and pharmaceutical contents of . Concentrations and uptake of the concerned nutrients were gradually increased with the increased levels of PM except NPKS which were highest in sole application of IF. The aloin concentration of leaf was gradually increased with the increased level of PM and by 42.44% over control. The highest chlorophyll, total phenolic and flavonoid concentrations were found in the plants receiving the treatment IFPM except protein content which was obtained from IFPM. Significant and positive relationships between N and S with P concentrations and P and S with K concentrations of leaf were noticed. Aloin, total phenolic and flavonoid concentrations were significantly and positively correlated with Mg, Fe and Mn concentrations of leaf. Farmers may be advised to cultivate applying 75% PM at the rate of 5 t ha along with 25% IF (N, P, K and S at the rate of 150, 80, 120 and 30 kg ha, respectively) for obtaining better quality leaf in terms of nutrients and pharmaceutical compounds under the agro-climatic conditions of the study area.
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http://dx.doi.org/10.1016/j.heliyon.2021.e07464 | DOI Listing |
Anticancer Agents Med Chem
January 2025
Department of Biochemistry, Faculty of Science, Selcuk University, Konya, Turkiye.
Introduction/objective: Plants and their bioactive compounds play a crucial role in the pharmaceutical industry for treating cancer. To date, the cytotoxic and antiproliferative effects of Hypericum perforatum methanol extract on human thyroid cancer cell lines have not been thoroughly explored. The present study aimed to assess the potential anti-cancer effects of HPME on human thyroid cancer and investigate its potential therapeutic benefits.
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January 2025
Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Cancer is one of the most devastating illnesses in the world, impacting millions of individuals every year. Despite various therapies, the final effect is unsatisfactory. Chemotherapy currently dominates as the primary option of treatment.
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January 2025
Laboratory of Pharmaceutical Biotechnology and Bioinformatics, Department of Genetic Engineering and Biotechnology, Jashore University of Science and Technology, Jashore, 7408, Bangladesh.
Background: Breast cancer is a frequently diagnosed malignant disease and the primary cause of mortality among women with cancer worldwide. The therapy options are influenced by the molecular subtype due to the intricate nature of the condition, which consists of various subtypes. By focusing on the activation of receptors, Epidermal Growth Factor Receptor (EGFR) tyrosine kinase can be utilized as an effective drug target for therapeutic purposes of breast cancer.
View Article and Find Full Text PDFDrug Des Devel Ther
January 2025
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia.
Purpose: Phytosome technology, an advanced lipid-based delivery system, offers a promising solution for enhancing the bioavailability and therapeutic efficacy of secondary metabolites, particularly in cancer treatment. These metabolites, such as flavonoids, terpenoids, and alkaloids, possess significant anticancer potential but are often limited by poor solubility and low absorption. This review aims to investigate how phytosome encapsulation improves the pharmacokinetic profiles and anticancer effectiveness of these bioactive compounds.
View Article and Find Full Text PDFACS Pharmacol Transl Sci
January 2025
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, Schnackenburgallee 114, 22525 Hamburg, Germany.
The SARS-CoV-2 papain-like protease PLpro has multiple roles in the viral replication cycle, related to both its polypeptide cleavage function and its ability to antagonize the host immune response. Targeting the PLpro function is recognized as a promising mechanism to modulate viral replication, while supporting host immune responses. However, the development of PLpro-specific inhibitors remains challenging.
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