Background: The pathophysiology underlying the progression and development of autoimmune conditions, such as Rheumatoid Arthritis (RA), is a result of dysregulations of the immune system. Research has explored the genetic alterations present in RA; however, limited studies have examined the role of Killer cell Immunoglobulin-like Receptors () and Human Leukocyte Antigen () molecules in RA. Therefore, the aim of this study was to examine genes, their ligands, and compounds in patients with RA.
Methods: In this case-control study, a total of 50 patients with RA and 100 healthy individuals were enrolled. DNA samples were evaluated using PCR with sequence specific Primers (PCR-SSP). Odds ratio (OR) with a 95% confidence interval (CI) were reported.
Results: Among the genes examined, (p= 0.0255, OR= 0.389, 95% CI= 0.210-0.722) and (p< 0.0001, OR= 6.163, 95% CI= 3.174-11.968) were observed to have a statistically significant correlation with disease susceptibility to RA. As an inhibitory gene, was observed to have a protective effect against RA while as an activating gene, was found to increase risk for RA. No significant associations were found between any of the other genotypes, ligands, or compounds examined in this study to RA susceptibility.
Conclusion: In this study of RA in the Lur population of Iran, was observed to increase susceptibility to RA, while was found to act as a protecting factor based on both the cross Table and regression analyses. Further research should focus on repeating this study in additional populations.
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| http://dx.doi.org/10.52547/rbmb.10.1.84 | DOI Listing |
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