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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277936 | PMC |
| http://dx.doi.org/10.3389/fmolb.2021.719978 | DOI Listing |
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Modern plant breeding technologies have played a central role in addressing global food security challenges. These technologies, including next-generation sequencing (NGS) and multi-omics analysis, genome-wide association analysis (GWAS), genome editing and transgenics, machine learning, and speed breeding, have been improving crop yield and quality as well as crop adaptability under climate change conditions, such as tolerance to both biotic and abiotic stresses. Furthermore, identification, searching, assessment, and combining desirable integrated (morphological, physiological, and biochemical) attributes have been achieved with greater accuracy, efficiency, time, and cost-effectiveness, all of which are essential to meeting global food demands.
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The tumor microenvironment (TME) plays a crucial role in tumor progression and immunoregulation. Major histocompatibility complex class II (MHC-II) is essential for immune surveillance within the TME. While MHC-II genes are typically expressed by professional antigen-presenting cells, they are also expressed in tumor cells, potentially facilitating antitumor immune responses.
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