Background: Skin aging is the most common dermatological problem caused by intrinsic and extrinsic factor, such as exposure to (ultraviolet) UV rays. Chlorogenic acid (CA) is a phenolic compound which is known for its antioxidant properties against oxidative stress.
Objective: This study investigates the antiaging and anti-inflammatory properties of CA on UV-induced skin fibroblast cells.
Methods: Anti-inflammatory properties of CA were assessed by measuring inflammatory-related proteins IL-1β and TNF-α, while antiaging properties of CA were assessed by measuring reactive oxygen species (ROS), apoptosis, live and necrotic cells, and COL-3 gene expression level.
Results: Treating UV-induced skin fibroblast cells with CA decreased the level of ROS, IL-1β, TNF-α, apoptotic cells, and necrotic cells and increased live cells and COL-3 gene expression.
Conclusion: CA has the potential as the protective compound against inflammation and aging by decreasing the level ROS, pro-inflammatory cytokines IL-1β and TNF-α, apoptotic cells, and necrotic cells and by increasing live cells and COL-3 gene expression.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272460 | PMC |
| http://dx.doi.org/10.7717/peerj.11419 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cervical lymph node tuberculosis and TNF, IL8, IL10, IL12B and IFNG polymorphisms.
New Microbiol
January 2021
Departamento de Biología Molecular e Histocompatibilidad, Hospital General "Dr. Manuel Gea González", Calzada de Tlalpan 4800, Col. Sección XVI, CP 14080, Ciudad de México, México.
Cervical lymph node tuberculosis (LNTB) is the most common manifestation of extrapulmonary tuberculosis, resulting from the interaction of environmental and genetic factors. The immune response against TB is regulated by several cytokines, which have single nucleotide polymorphisms (SNPs), leading to different levels of expression. The aim of this study was to evaluate the association of LNTB with the TNF, IL8, IL10, IL12B and IFNG gene polymorphisms in Mexican patients.
View Article and Find Full Text PDFEffect of donor tumor necrosis factor-alpha and interleukin-10 genotypes on delayed graft function and acute rejection in kidney transplantation.
Iran J Kidney Dis
March 2013
Physiology Research Center; Department of Nephrology and Renal Transplantation, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran.
Introduction: This study evaluated the influence of interleukin-10 (IL10) gene -1082G>A and tumor necrosis factor-alpha (TNF) gene -308G>A polymorphisms in the donor and recipients on the acute rejection (AR) episodes and delayed graft function (DGF) in kidney transplant recipients.
Materials And Methods: The IL10 -1082G>A and TNF -308G>A polymorphisms were determined in 100 kidney allograft recipients and their donors using the polymerase chain reaction-amplification refractory mutation system polymerase chain reaction-restriction fragment length polymorphism methods. Transplantation outcomes were determined in terms of AR and DGF criteria.
Association of tumor necrosis factor alpha and its receptor polymorphisms with rheumatoid arthritis in female patients.
Cell Immunol
December 2011
Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Article Synopsis
- * Researchers analyzed blood samples from 172 RA patients and 160 healthy controls to look for variations in these genes using PCR-RFLP techniques.
- * Results indicate that the TNF-α 308AA genotype and the TNFRII 196M/R polymorphism are connected to higher susceptibility to RA, while the TNF-α 308GG genotype is linked to greater disease severity.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!