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Living with a central nervous system (CNS) tumor: findings on long-term survivorship from the NIH Natural History Study. | LitMetric

AI Article Synopsis

  • Primary CNS tumors lead to significant symptoms and a poor prognosis, prompting a study on long-term survivors (≥5 years) to evaluate their reported outcomes.
  • Data from 248 adult survivors revealed that while 42% reported no moderate-to-severe symptoms, many experienced issues like fatigue and cognitive difficulties, with significant anxiety and depression reported by some.
  • The study highlights the need for tailored survivorship care programs, as survivors exhibited diverse symptom experiences regardless of tumor characteristics, indicating ongoing support and research are essential.

Article Abstract

Background: Primary central nervous system (CNS) tumors are often associated with high symptom burden and a poor prognosis from the time of diagnosis. The purpose of this study is to describe patient-reported outcomes (PRO) data from long-term survivors (LTS; ≥5-year survival post-diagnosis).

Methods: Clinical/treatment/molecular characteristics and PROs (symptom burden/interference (MDASI-BT/SP), perceived cognition (Neuro-QoL), anxiety/depression (PROMIS), and general health status (EQ-5D-3L)) were collected on 248 adult LTS between 9/2016 and 8/2019. Descriptive statistics and regression analysis were used to report results.

Results: Participants had a median age of 47 years (19-82) and were primarily White (83%) males (51%) with high-grade tumors (59%) and few mutations. Forty-two percent of the 222 brain tumor LTS reported no moderate-to-severe symptoms, whereas 45% reported three or more; most common symptoms were fatigue (40%), difficulty remembering (29%), and drowsiness (28%). Among spine tumor LTS (n = 42), nearly half reported moderate-to-severe weakness, pain, fatigue, and numbness/tingling, with 72% experiencing activity-related interference. Severe anxiety, depression, and cognitive symptoms were reported in up to 23% of the sample. Brain tumor LTS at higher risk for severe symptoms were more likely to be young, unemployed, and have poor KPS (Karnofsky Performance Status), whereas high symptom-risk spinal cord tumor LTS had poor KPS and received any tumor treatment.

Conclusions: Findings indicate LTS fall into distinct cohorts with no significant symptoms or very high symptom burden, regardless of tumor grade or mutational profile. These LTS data demonstrate the need for survivorship care programs and future studies to explore the symptom trajectory of all CNS tumor patients for prevention and early interventions.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278352PMC
http://dx.doi.org/10.1093/nop/npab022DOI Listing

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